TMBIM6 and HJV

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	HJV
Description		transmembrane BAX inhibitor motif containing 6	hemojuvelin BMP co-receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Extracellular Space Plasma Membrane Cell Surface Membrane BMP Receptor Complex Side Of Membrane Plasma Membrane Protein Complex HFE-transferrin Receptor Complex
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Signaling Receptor Binding Protein Binding Coreceptor Activity BMP Binding BMP Receptor Activity Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Protein Autoprocessing BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To BMP Stimulus
Pathways			Netrin-1 signaling
Drugs
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		General cognitive ability ( 29844566)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	1 interacting genes: TMBIM6
Entrez ID		7009	148738
HPRD ID		02851	10521
Ensembl ID		ENSG00000139644	ENSG00000168509
Uniprot IDs		P55061	A8K466 Q6ZVN8
PDB IDs			4UI1 6Z3L
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoribonuclease Inhibitor Activity Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cytosolic Calcium Ion Concentration IRE1-mediated Unfolded Protein Response Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Immunoglobulin Production Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Calcium Ion Transport Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Immunoglobulin Production Response To Unfolded Protein Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Monoatomic Ion Transport Response To Amino Acid Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing Intracellular Calcium Ion Homeostasis Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Autophagy
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