TMBIM6 and COBLL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	COBLL1
Description		transmembrane BAX inhibitor motif containing 6	cordon-bleu WH2 repeat protein like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cell Cortex Membrane Extracellular Exosome
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Actin Binding Actin Monomer Binding Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Blood glucose levels ( 31928498) Body composition traits ( 30026463) Body fat percentage ( 26833246) Body mass index ( 25673413 26426971 29381148) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) circulating leptin levels ( 26833098 32917775) circulating leptin levels adjusted for BMI ( 26833098 32917775) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Fasting insulin ( 34059833) Glomerular filtration rate in chronic kidney disease ( 26420894) Glycine levels ( 30837465) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Heschl's gyrus morphology ( 25130324) High density lipoprotein cholesterol levels ( 31928498 33339817) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin concentration ( 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Response to statin therapy ( 20339536) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sexual dimorphism in anthropometric traits ( 23754948) Systolic blood pressure ( 30578418) Triglyceride levels ( 30698716 31928498 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20686565) Two-hour glucose ( 34059833) Type 2 diabetes ( 30054458 30297969 30718926 31118516) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 23563607 25673412 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971 28552196 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	2 interacting genes: TMBIM6 USP7
Entrez ID		7009	22837
HPRD ID		02851	10844
Ensembl ID		ENSG00000139644	ENSG00000082438
Uniprot IDs		P55061	A0A0D9SG04 A0A0X1KG75 B7Z2P5 Q53SF7
PDB IDs			2DAJ
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Negative Regulation Of Calcium Ion Transport Into Cytosol Endoribonuclease Inhibitor Activity Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Cellular Localization Monoubiquitinated Protein Deubiquitination IRE1-mediated Unfolded Protein Response Negative Regulation Of Immunoglobulin Production DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Cellular Response To Unfolded Protein Negative Regulation Of Cellular Response To Hypoxia Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Regulation Of Telomere Capping K48-linked Deubiquitinase Activity Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cellular Response To Hypoxia Endoplasmic Reticulum Calcium Ion Homeostasis Deubiquitinase Activity Negative Regulation Of RNA Splicing Cellular Response To Topologically Incorrect Protein Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Gene Expression Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Calcium Ion Transport Nucleotide-excision Repair Regulation Of Gluconeogenesis Negative Regulation Of Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Negative Regulation Of Proteasomal Protein Catabolic Process
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