TMBIM6 and CERS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMBIM6	CERS2
Gene Name		transmembrane BAX inhibitor motif containing 6	ceramide synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function		DNA Binding Protein Binding Sphingosine N-acyltransferase Activity
	Biological Process	Response To Unfolded Protein Endoplasmic Reticulum Calcium Ion Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		4 interactors: BCL2 BCL2L1 CERS2 VTI1A	9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		7009	29956
HPRD ID		02851	06080
Ensembl ID		ENSG00000139644	ENSG00000143418
Uniprot IDs		F8W034 P55061	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Anoikis Regulation Of Anoikis Release Of Cytochrome C From Mitochondria Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Organization Neuron Death Ovarian Follicle Development Apoptotic Mitochondrial Changes Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ovulation Cycle Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics Negative Regulation Of Cellular PH Reduction CD8-positive, Alpha-beta T Cell Lineage Commitment Apoptotic Process In Bone Marrow Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Membrane Organization Response To Ionizing Radiation Response To Alkaloid Mitochondrial Transport Male Gonad Development Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway Male Sex Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death Vesicle Organization Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Neuron Maturation Negative Regulation Of Mitotic Cell Cycle Gonad Development	Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		bax belongs beyond branch conserved embryos endoplasmic existence functionally grina homeostasis inositol manipulation melanogaster operating perk regulators reticulum similarly synergies synergistic transmembrane trisphosphate unfolded upregulated zebrafish	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Difference) ?		bax belongs beyond branch conserved embryos endoplasmic existence functionally grina homeostasis inositol manipulation melanogaster operating perk regulators reticulum similarly synergies synergistic transmembrane trisphosphate unfolded upregulated zebrafish	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Intersection) ?