TNFRSF17 and CMTM7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNFRSF17	CMTM7
Description		TNF receptor superfamily member 17	CKLF like MARVEL transmembrane domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endomembrane System Membrane	Extracellular Space Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Cytokine Activity Protein Binding
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway	B-1a B Cell Differentiation Chemotaxis Signal Transduction
Pathways		TNFs bind their physiological receptors
Drugs		Belantamab mafodotin Teclistamab Idecabtagene vicleucel Ciltacabtagene autoleucel
Diseases
GWAS		Blood protein levels ( 30072576) Phenylephrine infusion rate during anesthesia ( 31455332) QT interval ( 19305408) Testicular germ cell tumor ( 26503584)	Copper levels ( 26025379) Hallux valgus ( 32131869) IgM levels ( 28628107) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		8 interacting genes: CMTM7 PEX16 TMBIM6 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3	47 interacting genes: ADTRP AGER AQP6 ARL13B B3GAT1 BIK BSCL2 CD74 CD79A CLSTN3 CREB3L1 DAGLA DNAJC1 ELOVL4 FAM174A FAM209A FFAR2 FRMD3 GGT7 GORAB HAS3 HIBADH HSD17B13 LDLRAD1 LHFPL5 LMNA MS4A4A MUC1 PAGE1 PIANP PSMD6 RETREG3 SDC3 SHISA3 SLC14A2 SLC30A8 SSMEM1 STX1A TCTA TEX29 THAP4 TMEM106C TMEM174 TMEM31 TMPRSS2 TMX2 TNFRSF17
Entrez ID		608	112616
HPRD ID		00144	06988
Ensembl ID		ENSG00000048462	ENSG00000153551
Uniprot IDs		Q02223	F8WDZ3 Q96FZ5
PDB IDs		1OQD 1XU2 2KN1 4ZFO 6J7W 8HXQ 8HXR 8QY9 8QYA 8QYB
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding Regulation Of Immunoglobulin Production Signaling Adaptor Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Cytokine-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of DNA-binding Transcription Factor Activity Regulation Of Production Of Molecular Mediator Of Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Cytokine Activity Positive Regulation Of Immune Response Positive Regulation Of B Cell Proliferation Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction TORC2 Complex Disassembly Regulation Of B Cell Proliferation Lymphocyte Homeostasis ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization ABC-type Vitamin B12 Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Sphingolipid Transporter Activity Cell Death Apoptotic Process Endoribonuclease Inhibitor Activity Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Leukocyte Homeostasis Positive Regulation Of B Cell Activation Positive Regulation Of Germinal Center Formation Transitional One Stage B Cell Differentiation B-1a B Cell Differentiation Positive Regulation Of Immune System Process Signal Transduction Immune System Process Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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