TMBIM6 and VTI1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TMBIM6	VTI1A
Description		transmembrane BAX inhibitor motif containing 6	vesicle transport through interaction with t-SNAREs 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Golgi Membrane Cytoplasm Endosome Autophagosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Clathrin-coated Vesicle SNARE Complex Cytoplasmic Vesicle Late Endosome Membrane Trans-Golgi Network Membrane Neuronal Cell Body Neuron Projection Terminus Perinuclear Region Of Cytoplasm Bounding Membrane Of Organelle
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Autophagy Protein Transport Vesicle-mediated Transport Endosomal Transport Macroautophagy Endocytic Recycling Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Voluntary Musculoskeletal Movement Membrane Fusion
Pathways			Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness ( 30510157) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 25105248 26965516 30529582) Colorectal cancer or advanced adenoma ( 30510241) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Evening vs. morning chronotype (sMEQ score) ( 32579418) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Lung cancer ( 23143601) Multiple sclerosis ( 23412934) Non-glioblastoma glioma ( 28346443 26424050) Non-small cell lung cancer ( 31326317) QRS duration ( 27659466 30679814 31251759 27577874) Refractive error ( 32231278)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	2 interacting genes: STX16 TMBIM6
Entrez ID		7009	143187
HPRD ID		02851	18290
Ensembl ID		ENSG00000139644	ENSG00000151532
Uniprot IDs		P55061	A0A994J5N6 Q96AJ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Ganglioside Biosynthetic Process Via Lactosylceramide Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Negative Regulation Of Calcium Ion Transport Into Cytosol Endoribonuclease Inhibitor Activity Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of IRE1-mediated Unfolded Protein Response Golgi Membrane Sialyltransferase Activity Ganglioside Metabolic Process Keratan Sulfate Proteoglycan Biosynthetic Process Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Keratan Sulfate Proteoglycan Metabolic Process Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cytosolic Calcium Ion Concentration IRE1-mediated Unfolded Protein Response Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Immunoglobulin Production Golgi Cisterna Viral Protein Processing Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing Glycosphingolipid Biosynthetic Process Protein O-linked Glycosylation Via N-acetyl-galactosamine Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response SNAP Receptor Activity Negative Regulation Of Calcium Ion Transmembrane Transport
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