TMBIM6 and MANBAL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	MANBAL
Description		transmembrane BAX inhibitor motif containing 6	mannosidase beta like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	Appendicular lean mass ( 33097823)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	21 interacting genes: ATP13A1 CACNA1A CATSPERH CMTM2 GPR151 KLK5 MALL MARCHF5 MPDU1 NIPAL3 OTOP2 PIGF SCRG1 SLC39A9 STX3 TMBIM6 TMEM115 TMEM203 UBQLN1 VKORC1 VTI1B
Entrez ID		7009	63905
HPRD ID		02851	14356
Ensembl ID		ENSG00000139644	ENSG00000101363
Uniprot IDs		P55061	A2A2E0 Q9NQG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Membrane Endoplasmic Reticulum Membrane Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Monoatomic Ion Transport Metal Ion Transport Endoplasmic Reticulum SNARE Complex Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane SNAP Receptor Activity Intracellular Calcium Ion Homeostasis Endoribonuclease Inhibitor Activity Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Negative Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Autophagosome Maturation Presynaptic Endosome Membrane Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vesicle Docking Monoatomic Ion Homeostasis SNARE Binding Negative Regulation Of Cation Transmembrane Transport Chemical Homeostasis Ethanolaminephosphotransferase Activity Intracellular Chemical Homeostasis Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Toll-like Receptor 3 Signaling Pathway P-type Transmembrane Transporter Activity
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