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OPRM1 and GNA15
Number of citations of the paper that reports this interaction (PMID
9572309
)
8
Data Source:
HPRD
(in vivo)
OPRM1
GNA15
Gene Name
opioid receptor, mu 1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Dendrite Membrane
Dendrite Cytoplasm
Sarcolemma
Neuron Projection
Perikaryon
Membrane Raft
Heterotrimeric G-protein Complex
Plasma Membrane
Molecular Function
G-protein Alpha-subunit Binding
G-protein Coupled Receptor Activity
Beta-endorphin Receptor Activity
Voltage-gated Calcium Channel Activity
Protein Binding
Protein Domain Specific Binding
Filamin Binding
G-protein Beta-subunit Binding
Morphine Receptor Activity
Neuropeptide Binding
G-protein Coupled Receptor Binding
GTPase Activity
Signal Transducer Activity
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Metal Ion Binding
Biological Process
Acute Inflammatory Response To Antigenic Stimulus
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Neuropeptide Signaling Pathway
Synaptic Transmission
Sensory Perception
Locomotory Behavior
Negative Regulation Of Cell Proliferation
Sensory Perception Of Pain
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Response To Food
Positive Regulation Of Appetite
Response To Lipopolysaccharide
Cellular Response To Stress
Wound Healing
Response To Cocaine
Positive Regulation Of CAMP-mediated Signaling
Negative Regulation Of CAMP-mediated Signaling
Negative Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Behavioral Response To Ethanol
Positive Regulation Of Neurogenesis
Negative Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Sensory Perception Of Pain
Regulation Of Excitatory Postsynaptic Membrane Potential
Negative Regulation Of Wnt Protein Secretion
Positive Regulation Of ERK1 And ERK2 Cascade
Calcium Ion Transmembrane Transport
Response To Growth Factor
Cellular Response To Morphine
Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway
Blood Coagulation
Platelet Activation
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Peptide ligand-binding receptors
G-protein activation
Class A/1 (Rhodopsin-like receptors)
Opioid Signalling
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Signaling by GPCR
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
Regulation of insulin secretion
Signal amplification
Thrombin signalling through proteinase activated receptors (PARs)
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
Platelet activation, signaling and aggregation
Free fatty acids regulate insulin secretion
Drugs
Tramadol
Morphine
Codeine
Hydromorphone
Methadone
Oxycodone
Levallorphan
Butorphanol
Propoxyphene
Pentazocine
Naltrexone
Sufentanil
Alfentanil
Fentanyl
Loperamide
Nalbuphine
Levorphanol
Remifentanil
Ondansetron
Anileridine
Buprenorphine
Hydrocodone
Diphenoxylate
Naloxone
Oxymorphone
Dezocine
Levomethadyl Acetate
Methadyl Acetate
3-Methylthiofentanyl
Dimethylthiambutene
Heroin
Ethylmorphine
Etorphine
Carfentanil
Diprenorphine
Dihydromorphine
3-Methylfentanyl
Tapentadol
Alvimopan
Methylnaltrexone
Diseases
GWAS
Coronary heart disease (
21347282
)
Heart failure (
20445134
)
Protein-Protein Interactions
23 interactors:
ADRBK2
CALM1
COPS5
DNAJB4
DOK4
DOK5
FLNA
GNA15
GNAI1
GNAI2
GNAO1
GPRASP1
KCNF1
OPRD1
PLD2
PPL
RANBP9
SIAH1
SIAH2
UBC
VAPA
WLS
ZYX
19 interactors:
ADRB2
ADRBK1
APP
CHRM2
CNR1
CNR2
CXCR1
CXCR2
F2R
GRM2
GRM4
HRH4
LTB4R
OPRD1
OPRK1
OPRM1
PRKCA
RGS2
TTC1
Entrez ID
4988
2769
HPRD ID
02484
00760
Ensembl ID
ENSG00000112038
ENSG00000060558
Uniprot IDs
P35372
P30679
PDB IDs
Enriched GO Terms of Interacting Partners
?
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Signaling
Cell Communication
Cell Surface Receptor Signaling Pathway
Platelet Activation
Signal Transduction
Regulation Of Signal Transduction
Response To Stimulus
Dopamine Receptor Signaling Pathway
Regulation Of Signaling
Synaptic Transmission
Cell-cell Signaling
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Calcium Ion Transport
Cellular Response To Stimulus
Blood Coagulation
Hemostasis
Establishment Of Localization In Cell
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Receptor Metabolic Process
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cellular Localization
Regulation Of Cellular Process
Regulation Of Ion Transport
Vesicle-mediated Transport
Cell Activation
Cytoplasmic Transport
Response To Wounding
Cell Projection Organization
Negative Regulation Of Signaling
Response To Stress
Negative Regulation Of Calcium Ion Transport
Receptor Internalization
Transport
Nervous System Development
Neuron Projection Development
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Endosomal Transport
Membrane Organization
Cellular Process
Activation Of Phospholipase C Activity
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Defense Response
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Signaling
Cell Communication
Sensory Perception Of Pain
Cellular Metal Ion Homeostasis
Inflammatory Response
Response To External Stimulus
Opioid Receptor Signaling Pathway
Cellular Cation Homeostasis
Cellular Response To Stimulus
Cellular Ion Homeostasis
Metal Ion Homeostasis
Regulation Of Phosphorus Metabolic Process
Cellular Chemical Homeostasis
Blood Circulation
Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Muscle Contraction
Response To Stress
Chemical Homeostasis
Ion Homeostasis
Synaptic Transmission
Regulation Of Cyclase Activity
Immune Response
Regulation Of Phosphorylation
Cytosolic Calcium Ion Homeostasis
Regulation Of MAPK Cascade
Regulation Of Catalytic Activity
Homeostatic Process
Regulation Of Signaling
Interleukin-8-mediated Signaling Pathway
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Cellular Homeostasis
Negative Regulation Of Muscle Contraction
Negative Regulation Of Adenylate Cyclase Activity
Regulation Of CAMP Biosynthetic Process
Negative Regulation Of Lyase Activity
Response To Stimulus
Regulation Of CAMP Metabolic Process
Regulation Of Sensory Perception Of Pain
Negative Regulation Of Catalytic Activity
Tagcloud
?
13qter
9p
acp5
cckbr
cholecystokinin
chro
chromosomes
converter
eleven
ends
fall39
glycoprotein
integrin
itgam
itgbeta2
linkage
mapping
mu
opioid
pc1
pellucida
rbp3
retinol
rflp
rnr1
ssc
swine
zona
zp1
Tagcloud (Difference)
?
13qter
9p
acp5
cckbr
cholecystokinin
chro
chromosomes
converter
eleven
ends
fall39
glycoprotein
integrin
itgam
itgbeta2
linkage
mapping
mu
opioid
pc1
pellucida
rbp3
retinol
rflp
rnr1
ssc
swine
zona
zp1
Tagcloud (Intersection)
?