OPRM1 and DNAJB4

Number of citations of the paper that reports this interaction (PMID 16542645)
4

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		OPRM1	DNAJB4
Gene Name		opioid receptor, mu 1	DnaJ (Hsp40) homolog, subfamily B, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding	Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Locomotory Behavior Negative Regulation Of Cell Proliferation Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide Cellular Response To Stress Wound Healing Response To Cocaine Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity	Protein Folding Response To Unfolded Protein Response To Heat
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G-protein activation Class A/1 (Rhodopsin-like receptors) Opioid Signalling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Tramadol Morphine Codeine Hydromorphone Methadone Oxycodone Levallorphan Butorphanol Propoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Levomethadyl Acetate Methadyl Acetate 3-Methylthiofentanyl Dimethylthiambutene Heroin Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl Tapentadol Alvimopan Methylnaltrexone
Diseases
GWAS		Coronary heart disease ( 21347282)
Protein-Protein Interactions		23 interactors: ADRBK2 CALM1 COPS5 DNAJB4 DOK4 DOK5 FLNA GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 KCNF1 OPRD1 PLD2 PPL RANBP9 SIAH1 SIAH2 UBC VAPA WLS ZYX	8 interactors: HSPA6 MDM2 OPRM1 PABPN1 POLR1D SMAD3 TBL1X TBPL2
Entrez ID		4988	11080
HPRD ID		02484	07486
Ensembl ID		ENSG00000112038
Uniprot IDs		P35372	B4DNN2 Q9UDY4
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Platelet Activation Signal Transduction Regulation Of Signal Transduction Response To Stimulus Dopamine Receptor Signaling Pathway Regulation Of Signaling Synaptic Transmission Cell-cell Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Calcium Ion Transport Cellular Response To Stimulus Blood Coagulation Hemostasis Establishment Of Localization In Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Receptor Metabolic Process G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cellular Localization Regulation Of Cellular Process Regulation Of Ion Transport Vesicle-mediated Transport Cell Activation Cytoplasmic Transport Response To Wounding Cell Projection Organization Negative Regulation Of Signaling Response To Stress Negative Regulation Of Calcium Ion Transport Receptor Internalization Transport Nervous System Development Neuron Projection Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Endosomal Transport Membrane Organization Cellular Process Activation Of Phospholipase C Activity	Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Initiation Cellular Response To Alkaloid Response To Morphine Response To Cocaine Negative Regulation Of Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription, DNA-templated DNA-templated Transcription, Termination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Wnt Protein Secretion Positive Regulation Of Transforming Growth Factor Beta3 Production Cellular Response To UV-C Cellular Response To Vitamin B1 Transcription, DNA-templated Response To Ammonium Ion RNA Biosynthetic Process Immune Response Interaction With Host Positive Regulation Of Nucleocytoplasmic Transport Viral Process Modification By Virus Of Host MRNA Processing Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Growth Factor Regulation Of Protein Transport Regulation Of Protein Stability Evasion Or Tolerance Of Host Defenses By Virus Response To Alkaloid Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To Morphine Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Appetite Response To Vitamin B1 Response To Ether Cellular Response To Isoquinoline Alkaloid Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Primary MiRNA Processing
Tagcloud ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	affinities anthanogene bag bag1 bag2 bag3 bcl2 chaperones cochaperones combinations combinatorial compete competed dnaja1 dnaja2 generate hierarchy hsp105 hsp70 hsp72 hspa1a mammals nef nefs permutations refolding stoichiometry unrelated
Tagcloud (Difference) ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	affinities anthanogene bag bag1 bag2 bag3 bcl2 chaperones cochaperones combinations combinatorial compete competed dnaja1 dnaja2 generate hierarchy hsp105 hsp70 hsp72 hspa1a mammals nef nefs permutations refolding stoichiometry unrelated
Tagcloud (Intersection) ?