OPRM1 and CPLX1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		OPRM1	CPLX1
Description		opioid receptor mu 1	complexin 1
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Cell Projection Neuron Projection Perikaryon Synapse	Cytoplasm Cytosol Dendrite SNARE Complex Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Perikaryon Calyx Of Held Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity G Protein-coupled Opioid Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding G Protein-coupled Peptide Receptor Activity G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding	SNARE Binding Protein Binding Syntaxin-1 Binding Syntaxin Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Negative Regulation Of Cell Population Proliferation Sensory Perception Of Pain G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Morphine Regulation Of Cellular Response To Stress Regulation Of NMDA Receptor Activity	Neurotransmitter Transport Exocytosis Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane
Pathways		Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Meperidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levacetylmethadol Aripiprazole Methadyl acetate 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Naloxegol Cannabidiol Trimebutine Butyrfentanyl Pholcodine Eluxadoline Tianeptine Opium Pentoxyverine Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol Oliceridine
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Hypertension ( 21347282) Lipoprotein (a) levels ( 26377243) Menstruation quality of life impact (fever) ( 29855537) Methadone dose in opioid dependence ( 28115739) Nontraumatic osteonecrosis of the femoral head ( 32701715) Opioid use disorder ( 32492095) Type 2 diabetes (age of onset) ( 28060188)	Behcet's disease ( 33393726) Heel bone mineral density ( 30598549)
Interacting Genes		78 interacting genes: ADAM33 ADD3 ALOX5AP ATP6V0C ATP6V0E1 C2CD2L CALM1 CCDC167 CD302 CLCN7 CLDN10 CLDN22 CLDN8 CLEC12B CLEC7A CNIH1 COPS5 CPLX1 CTXN3 CYB561 DNAJB4 DOK4 DOK5 DRD2 EHHADH EMP1 EMP3 FLNA GJA4 GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 GRM1 HS6ST1 IFITM3 KCNF1 LAT LPAR3 LRRC25 MAL MALL MAP1LC3A MAP1LC3C MFF NELFA NSG1 OPRD1 OPRL1 PLD2 PLD3 PMP22 PPL RPRM RTP4 SCGB1D1 SEC22A SERP2 SIAH1 SIAH2 SLC30A2 SLC38A7 SLC39A13 SLC41A1 SLC9A9 SMAGP TEX264 TM4SF4 TMBIM6 TMEM236 TRARG1 UBC VAPA WLS YIPF3 ZYX	6 interacting genes: AGTRAP CMTM5 OPRM1 SNAP25 STX1A VAMP2
Entrez ID		4988	10815
HPRD ID		02484	09233
Ensembl ID		ENSG00000112038	ENSG00000168993
Uniprot IDs		A0A6H0WF09 B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372	O14810
PDB IDs		8EF5 8EF6 8EFB 8EFL 8EFO 8EFQ 8F7Q 8F7R 8K9K 8K9L 9MQH 9MQI 9MQJ	3RK3 3RL0
Enriched GO Terms of Interacting Partners?		Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Plasma Membrane Bleb Assembly Cytoplasmic Vesicle Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Protein Binding Intracellular Monoatomic Cation Homeostasis Heterotrimeric G-protein Complex Intracellular Monoatomic Ion Homeostasis G Protein-coupled Receptor Binding Lysosomal Membrane Monoatomic Cation Homeostasis G Protein-coupled Serotonin Receptor Binding Monoatomic Ion Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transport Adenylate Cyclase Regulator Activity Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Monoatomic Cation Transport G Protein-coupled Dopamine Receptor Signaling Pathway Intracellular Chemical Homeostasis Transmembrane Transport Regulation Of Metal Ion Transport Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Endoplasmic Reticulum Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Bicellular Tight Junction Inorganic Ion Transmembrane Transport Phospholipase D Activity Cell-cell Signaling Membrane Raft Distribution G Protein-coupled Opioid Receptor Activity Anchoring Junction Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Signaling Membrane Raft Localization Cellular Homeostasis Vesicle-mediated Transport Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Proton-transporting V-type ATPase, V0 Domain Cell Communication	Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Calcium-ion Regulated Exocytosis SNAP Receptor Activity Synaptic Vesicle Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex SNARE Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex SNARE Binding Calcium-dependent Protein Binding Voltage-gated Potassium Channel Complex Neuron Projection Vesicle-mediated Transport In Synapse Vesicle Fusion Organelle Membrane Fusion Regulated Exocytosis Regulation Of Protein Transport Synaptic Vesicle Docking SNARE Complex Assembly Organelle Fusion Synaptic Vesicle Positive Regulation Of Synaptic Transmission Regulation Of Establishment Of Protein Localization Membrane Fusion Syntaxin-1 Binding Regulation Of Secretion By Cell Signal Release Regulation Of Secretion Exocytosis Regulation Of Protein Secretion Regulation Of Hormone Secretion Synaptic Vesicle Endocytosis Vesicle Docking Involved In Exocytosis Presynaptic Endocytosis Regulation Of Protein Localization Synapse Vesicle Organization Long-term Synaptic Potentiation Vesicle Docking Secretion By Cell Axon Regulation Of Transmembrane Transporter Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Myosin Head/neck Binding Membrane Docking Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission
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