CERS2 and PEX6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CERS2	PEX6
Description		ceramide synthase 2	peroxisomal biogenesis factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Photoreceptor Outer Segment Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Cell Projection Photoreceptor Cell Cilium
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Response To Immobilization Stress Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Stabilization
Pathways		Sphingolipid de novo biosynthesis	Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Estimated glomerular filtration rate ( 31015462 31152163) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)	Alzheimer's disease in APOE e4+ carriers ( 25778476) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ASGR1 ASGR2 ATP6V0C CERS6 DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 UBC YIF1A	8 interacting genes: ATF7IP CERS2 PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3
Entrez ID		29956	5190
HPRD ID		06080	03293
Ensembl ID		ENSG00000143418	ENSG00000124587
Uniprot IDs		Q96G23	Q13608
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Response To Hypoxia Asialoglycoprotein Receptor Activity Regulation Of Cellular Response To Hypoxia Transmembrane Transport Ubiquitin Protein Ligase Binding Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Transmembrane Transport Membrane Fucose Binding Catecholamine Uptake Dopamine Uptake Protein Unfolding Azole Transmembrane Transport Plasma Membrane Pyrimidine-containing Compound Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Vitamin Transmembrane Transport Dopamine Transport Neurotransmitter Reuptake D-mannose Binding Monoatomic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Establishment Of Localization In Cell Monoamine Transport Neurotransmitter Uptake Organic Hydroxy Compound Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport COPII-coated ER To Golgi Transport Vesicle Pattern Recognition Receptor Activity Response To Cocaine Vitamin Transport CTP Binding DATP Binding Positive Regulation Of Glutathione Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Monoatomic Ion Transport Lateral Plasma Membrane G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Carboxylic Acid Transport Organic Acid Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding	Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Receptor Metabolic Process Protein Import Into Peroxisome Membrane Peroxisomal Membrane Protein Transmembrane Transport Protein Targeting To Peroxisome Peroxisome Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Cytosol Establishment Of Protein Localization To Organelle Positive Regulation Of Transforming Growth Factor Beta3 Production Microtubule-based Peroxisome Localization Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Cytosolic Ribosome Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Peroxisome Targeting Sequence Binding Negative Regulation Of Schwann Cell Migration Cytoplasmic Translation Regulation Of Lung Blood Pressure Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Intracellular Protein Transport Mesoderm Morphogenesis Immune System Development Structural Constituent Of Ribosome Protein To Membrane Docking Pericardium Development Protein Import Into Peroxisome Matrix, Substrate Release Sphingosine N-acyltransferase Activity Transdifferentiation SMAD Protein Complex Trophoblast Cell Migration Regulation Of Response To Wounding Protein Localization To Organelle Negative Regulation Of Glial Cell Migration DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Ribosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?