CERS2 and SLC22A1

Number of citations of the paper that reports this interaction (PMID 11543633)
7

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CERS2	SLC22A1
Gene Name		ceramide synthase 2	solute carrier family 22 (organic cation transporter), member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	DNA Binding Protein Binding Sphingosine N-acyltransferase Activity	Acetylcholine Transmembrane Transporter Activity Dopamine Transmembrane Transporter Activity Norepinephrine Transmembrane Transporter Activity Protein Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Protein Homodimerization Activity
	Biological Process	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process	Neurotransmitter Transport Drug Transmembrane Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Dopamine Transport Norepinephrine Transport Small Molecule Metabolic Process Epinephrine Transport Protein Homooligomerization Transmembrane Transport Ammonium Transmembrane Transport Acetate Ester Transport
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Na+/Cl- dependent neurotransmitter transporters Neurotransmitter Release Cycle Neurotransmitter Clearance In The Synaptic Cleft Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport Abacavir transport and metabolism Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)	Metabolic traits ( 21886157) Prostate cancer ( 21743057)
Protein-Protein Interactions		9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6	2 interactors: CERS2 POU2AF1
Entrez ID		29956	6580
HPRD ID		06080	04007
Ensembl ID		ENSG00000143418	ENSG00000175003
Uniprot IDs		Q96G23	O15245
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr	adopted agonists cation cml endocrine hence hoct1 imatinib improve killing leukaemia myeloid organic orphan peroxisome potentially ppar predictor pregnane proliferator pxr rank rar retinoid rxr transporter upregulated uptake wilcoxon
Tagcloud (Difference) ?		17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr	adopted agonists cation cml endocrine hence hoct1 imatinib improve killing leukaemia myeloid organic orphan peroxisome potentially ppar predictor pregnane proliferator pxr rank rar retinoid rxr transporter upregulated uptake wilcoxon
Tagcloud (Intersection) ?