SAT1 and ABCB8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SAT1	ABCB8
Gene Name		spermidine/spermine N1-acetyltransferase 1	ATP-binding cassette, sub-family B (MDR/TAP), member 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Nucleus Nucleolus Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane Integral Component Of Membrane ATP-binding Cassette (ABC) Transporter Complex
	Molecular Function	Diamine N-acetyltransferase Activity Protein Binding Spermidine Binding	Transporter Activity ATP Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Angiogenesis Polyamine Metabolic Process Polyamine Biosynthetic Process Putrescine Catabolic Process Spermidine Acetylation Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Small Molecule Metabolic Process	Transport Metabolic Process Transmembrane Transport
Pathways		Metabolism of polyamines Interconversion of polyamines Metabolism of amino acids and derivatives	Mitochondrial ABC transporters ABC-family proteins mediated transport
Drugs		N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
Diseases
GWAS
Protein-Protein Interactions		75 interactors: ABCB8 APLP1 B4GALT3 C14orf1 C19orf25 CASP7 CCDC148 CCDC90B CCHCR1 CHD3 COPS6 CRMP1 CSNK2A1 CSNK2A2 DDX39A DGKZ DMRT3 DNPEP EEF1G EIF3D EPHB6 EVA1A FAM156A FAM69B FAM86C1 FTSJ3 FUNDC2 GBP2 GDF9 GNB2L1 HIF1A HOXB6 HOXB9 HSPE1 INO80C ITGA9 JUNB KAT5 KAT7 KCNA4 KIAA1377 LNX1 LRIF1 LUC7L2 MED31 MRPL9 MTA1 NIF3L1 NMRK2 PLGRKT PRDX2 PTN RBM17 RBM48 REL RELA RPLP1 SARAF SAT2 SEPHS1 SETDB1 SNAI2 TACO1 TCF25 TLE1 TP53 TP53TG1 TSC22D4 TUBB2A UBE2D3 UNC119 UTP14A VASP VKORC1 ZHX1	2 interactors: NOA1 SAT1
Entrez ID		6303	11194
HPRD ID		02431	10400
Ensembl ID		ENSG00000130066	ENSG00000197150
Uniprot IDs		P21673 Q6ICU9	A5D8W3 B4DG02 G3XAP3 Q9NUT2
PDB IDs		2B3U 2B3V 2B4B 2B4D 2B58 2B5G 2F5I 2FXF 2G3T 2JEV
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Response To External Stimulus Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Gene Expression Chemotaxis Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Notch Signaling Pathway Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Locomotion Regulation Of Interleukin-12 Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Response To Ionizing Radiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Axon Guidance Response To Abiotic Stimulus	Spermidine Acetylation Putrescine Catabolic Process Oxalate Transport Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Regulation Of Cellular Respiration Neurotransmitter Uptake 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Polyamine Biosynthetic Process Amine Biosynthetic Process Polyamine Metabolic Process Sulfate Transmembrane Transport Sulfate Transport Neutral Amino Acid Transport Regulation Of Generation Of Precursor Metabolites And Energy Mitochondrial Translation Dicarboxylic Acid Transport Chloride Transmembrane Transport Amino Acid Transmembrane Transport Cellular Biogenic Amine Metabolic Process Chloride Transport Amine Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Regulation Of Neurotransmitter Levels Response To Xenobiotic Stimulus Amino Acid Transport Neurotransmitter Transport Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Glycosaminoglycan Metabolic Process Ribosome Biogenesis Sodium Ion Transmembrane Transport Pathogenesis Purine Nucleoside Metabolic Process
Tagcloud ?		acetyltransferase biologic catabolism chemoradiation databases dr dramatic explaining gbm glioblastoma ionizing lies mechanistically multiforme n1 neurosphere oncomine polyamine radiation radioresistance radiosensitization recombination referenced rembrandt sensitization sensitize shrna spermidine spermine	abcb1 abcb5 abcc1 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically
Tagcloud (Difference) ?		acetyltransferase biologic catabolism chemoradiation databases dr dramatic explaining gbm glioblastoma ionizing lies mechanistically multiforme n1 neurosphere oncomine polyamine radiation radioresistance radiosensitization recombination referenced rembrandt sensitization sensitize shrna spermidine spermine	abcb1 abcb5 abcc1 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically
Tagcloud (Intersection) ?