SAT1 and DNPEP

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SAT1	DNPEP
Gene Name		spermidine/spermine N1-acetyltransferase 1	aspartyl aminopeptidase
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Nucleus Nucleoplasm Cytoplasm Blood Microparticle
	Molecular Function	Diamine N-acetyltransferase Activity Protein Binding Spermidine Binding	Aminopeptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Angiogenesis Polyamine Metabolic Process Polyamine Biosynthetic Process Putrescine Catabolic Process Spermidine Acetylation Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Small Molecule Metabolic Process	Proteolysis Peptide Metabolic Process
Pathways		Metabolism of polyamines Interconversion of polyamines Metabolism of amino acids and derivatives
Drugs		N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
Diseases
GWAS			Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		75 interactors: ABCB8 APLP1 B4GALT3 C14orf1 C19orf25 CASP7 CCDC148 CCDC90B CCHCR1 CHD3 COPS6 CRMP1 CSNK2A1 CSNK2A2 DDX39A DGKZ DMRT3 DNPEP EEF1G EIF3D EPHB6 EVA1A FAM156A FAM69B FAM86C1 FTSJ3 FUNDC2 GBP2 GDF9 GNB2L1 HIF1A HOXB6 HOXB9 HSPE1 INO80C ITGA9 JUNB KAT5 KAT7 KCNA4 KIAA1377 LNX1 LRIF1 LUC7L2 MED31 MRPL9 MTA1 NIF3L1 NMRK2 PLGRKT PRDX2 PTN RBM17 RBM48 REL RELA RPLP1 SARAF SAT2 SEPHS1 SETDB1 SNAI2 TACO1 TCF25 TLE1 TP53 TP53TG1 TSC22D4 TUBB2A UBE2D3 UNC119 UTP14A VASP VKORC1 ZHX1	7 interactors: ADAMTSL4 AGT DGCR6 LNX1 MDFI MPP1 SAT1
Entrez ID		6303	23549
HPRD ID		02431	09924
Ensembl ID		ENSG00000130066	ENSG00000123992
Uniprot IDs		P21673 Q6ICU9	E7ETB3 Q9NV55 Q9ULA0
PDB IDs		2B3U 2B3V 2B4B 2B4D 2B58 2B5G 2F5I 2FXF 2G3T 2JEV	4DYO
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Response To External Stimulus Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Gene Expression Chemotaxis Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Notch Signaling Pathway Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Locomotion Regulation Of Interleukin-12 Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Response To Ionizing Radiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Axon Guidance Response To Abiotic Stimulus	Uterine Smooth Muscle Contraction Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Spermidine Acetylation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Catenin Import Into Nucleus Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Angiotensin-mediated Drinking Behavior Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Putrescine Catabolic Process Regulation Of Renal Output By Angiotensin Fibroblast Proliferation Astrocyte Activation Renin-angiotensin Regulation Of Aldosterone Production Oxalate Transport Regulation Of Blood Vessel Size By Renin-angiotensin Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity Establishment Of Blood-nerve Barrier MAPK Cascade Positive Regulation Of Activation Of Janus Kinase Activity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Artery Smooth Muscle Contraction Drinking Behavior Organ Morphogenesis Tonic Smooth Muscle Contraction Brain Renin-angiotensin System Activation Of Protein Kinase Activity Positive Regulation Of Cholesterol Esterification Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Superoxide Anion Generation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Anatomical Structure Morphogenesis Regulation Of Cholesterol Esterification Protein O-linked Fucosylation Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Transmission Of Nerve Impulse
Tagcloud ?		acetyltransferase biologic catabolism chemoradiation databases dr dramatic explaining gbm glioblastoma ionizing lies mechanistically multiforme n1 neurosphere oncomine polyamine radiation radioresistance radiosensitization recombination referenced rembrandt sensitization sensitize shrna spermidine spermine	2cl abundance alternatively ascending convoluted cotransporter ctal dct fl ko ks medullary microperfusion mtal nacl ncc nkcc2 osr1 reabsorption sodium spak spliced stimulatory tal thick tubule tubules vasopressin wt
Tagcloud (Difference) ?		acetyltransferase biologic catabolism chemoradiation databases dr dramatic explaining gbm glioblastoma ionizing lies mechanistically multiforme n1 neurosphere oncomine polyamine radiation radioresistance radiosensitization recombination referenced rembrandt sensitization sensitize shrna spermidine spermine	2cl abundance alternatively ascending convoluted cotransporter ctal dct fl ko ks medullary microperfusion mtal nacl ncc nkcc2 osr1 reabsorption sodium spak spliced stimulatory tal thick tubule tubules vasopressin wt
Tagcloud (Intersection) ?