TRA and CD247

Number of citations of the paper that reports this interaction (PMID 2138083)
29

Data Source:
HPRD (in vivo)

		TRA	CD247
Gene Name		T cell receptor alpha locus	CD247 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function		Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process		Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		15 interactors: CANX CD247 CD3D CD3G HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD UBC	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		6955	919
HPRD ID		01736	01729
Ensembl ID			ENSG00000198821
Uniprot IDs			P20963
PDB IDs			1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune System Process Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Peptide Antigen T Cell Costimulation Innate Immune Response Positive Regulation Of T Cell Activation Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Detection Of Bacterium Antigen Processing And Presentation Cellular Response To Cytokine Stimulus Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Cell Activation Signaling Detection Of Biotic Stimulus Cell Communication Regulation Of Cell Adhesion Response To Cytokine Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Lymphocyte Activation Defense Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Signal Transduction Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Interferon-gamma-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Response To Stress Fc Receptor Signaling Pathway Response To Organic Substance Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Organic Substance Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Cellular Response To Stimulus	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		activates adenocarcinoma agonists analogs beneficial cd du eliminate exhibits far indiscriminate inducing knockout morphogenesis natural possibly prostate rar rars retinoic retinoid retinoids reverses rxrs selective selectively synthetic undermined undesirable	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		activates adenocarcinoma agonists analogs beneficial cd du eliminate exhibits far indiscriminate inducing knockout morphogenesis natural possibly prostate rar rars retinoic retinoid retinoids reverses rxrs selective selectively synthetic undermined undesirable	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?