TRA

Description		T cell receptor alpha locus
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Detection Of Tumor Cell Immune System Process T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Bacterium
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		16 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TMUB1 TRAT1 TRB TRD
Entrez ID		6955
HPRD ID		01736
Ensembl ID
Uniprot IDs
PDB IDs
Enriched GO Terms of Interacting Partners?		Alpha-beta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Complex Lumenal Side Of Endoplasmic Reticulum Membrane Detection Of Biotic Stimulus Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Detection Of Bacterium T Cell Receptor Binding Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process ERAD Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Receptor Complex Antigen Processing And Presentation Of Endogenous Antigen TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding T Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response External Side Of Plasma Membrane Immune System Process Protection From Natural Killer Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Immune Response To Tumor Cell ER To Golgi Transport Vesicle Membrane Immune Response-regulating Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen MHC Class I Protein Complex Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Immune Response Clathrin-coated Endocytic Vesicle Membrane Regulation Of Immune System Process Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Lymphocyte Activation Protein Folding In Endoplasmic Reticulum Positive Thymic T Cell Selection Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Detection Of Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive T Cell Selection Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation
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