TRA and CD3G

Number of citations of the paper that reports this interaction (PMID 2138083)
29

Data Source:
HPRD (in vivo)

		TRA	CD3G
Gene Name		T cell receptor alpha locus	CD3g molecule, gamma (CD3-TCR complex)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Plasma Membrane Integral Component Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function		Transmembrane Signaling Receptor Activity Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Protein Heterodimerization Activity
	Biological Process		Protein Complex Assembly Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Lymphocyte Apoptotic Process
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse TCR signaling PD-1 signaling Role of phospholipids in phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Fcgamma receptor (FCGR) dependent phagocytosis Phosphorylation of CD3 and TCR zeta chains FCGR activation Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065)
Protein-Protein Interactions		15 interactors: CANX CD247 CD3D CD3G HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD UBC	5 interactors: CD3D CD3E TRA TRB TRD
Entrez ID		6955	917
HPRD ID		01736	07037
Ensembl ID
Uniprot IDs			B0YIY5 P09693
PDB IDs			1SY6
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune System Process Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Peptide Antigen T Cell Costimulation Innate Immune Response Positive Regulation Of T Cell Activation Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Detection Of Bacterium Antigen Processing And Presentation Cellular Response To Cytokine Stimulus Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Cell Activation Signaling Detection Of Biotic Stimulus Cell Communication Regulation Of Cell Adhesion Response To Cytokine Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Lymphocyte Activation Defense Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Signal Transduction Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Interferon-gamma-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Response To Stress Fc Receptor Signaling Pathway Response To Organic Substance Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Organic Substance Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Cellular Response To Stimulus	Thymic T Cell Selection T Cell Selection T Cell Differentiation In Thymus T Cell Costimulation T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion T Cell Aggregation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of T Cell Anergy Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Hemopoiesis Regulation Of T Cell Anergy Positive Regulation Of Immune Response Positive Thymic T Cell Selection Cell Activation Immune System Development Positive Regulation Of T Cell Tolerance Induction Negative Thymic T Cell Selection Signal Complex Assembly Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Negative T Cell Selection Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-2 Biosynthetic Process Positive T Cell Selection Positive Regulation Of Calcium-mediated Signaling
Tagcloud ?		activates adenocarcinoma agonists analogs beneficial cd du eliminate exhibits far indiscriminate inducing knockout morphogenesis natural possibly prostate rar rars retinoic retinoid retinoids reverses rxrs selective selectively synthetic undermined undesirable	aurkb bub1b ccnb1 cd247 cd3d cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Difference) ?		activates adenocarcinoma agonists analogs beneficial cd du eliminate exhibits far indiscriminate inducing knockout morphogenesis natural possibly prostate rar rars retinoic retinoid retinoids reverses rxrs selective selectively synthetic undermined undesirable	aurkb bub1b ccnb1 cd247 cd3d cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Intersection) ?