TRA and EDEM3

Number of citations of the paper that reports this interaction (PubMedID 29784879)
43

Data Source:
BioGRID (pull down)

		TRA	EDEM3
Description		T cell receptor alpha locus	ER degradation enhancing alpha-mannosidase like protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Signaling Receptor Activity	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Detection Of Tumor Cell Immune System Process T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Bacterium	Carbohydrate Metabolic Process Protein Glycosylation Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Ubiquitin-dependent Glycoprotein ERAD Pathway Endoplasmic Reticulum Mannose Trimming
Pathways			ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		16 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TMUB1 TRAT1 TRB TRD	2 interacting genes: TRA TXNDC5
Entrez ID		6955	80267
HPRD ID		01736	10724
Ensembl ID			ENSG00000116406
Uniprot IDs			A0A8J8YX80 Q9BZQ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Alpha-beta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Complex Lumenal Side Of Endoplasmic Reticulum Membrane Detection Of Biotic Stimulus Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Detection Of Bacterium T Cell Receptor Binding Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process ERAD Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Receptor Complex Antigen Processing And Presentation Of Endogenous Antigen TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding T Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response External Side Of Plasma Membrane Immune System Process Protection From Natural Killer Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Immune Response To Tumor Cell ER To Golgi Transport Vesicle Membrane Immune Response-regulating Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen MHC Class I Protein Complex Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Immune Response Clathrin-coated Endocytic Vesicle Membrane Regulation Of Immune System Process Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Lymphocyte Activation Protein Folding In Endoplasmic Reticulum Positive Thymic T Cell Selection Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Detection Of Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive T Cell Selection Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell T Cell Mediated Cytotoxicity T Cell Receptor Complex Beta-catenin Destruction Complex Nuclear Envelope Lumen S100 Protein Binding Response To Growth Hormone Intracellular Organelle Lumen Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Protein-lysine N-methyltransferase Activity
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