TRA and TRAT1

Number of citations of the paper that reports this interaction (PMID 11390434)
17

Data Source:
HPRD (in vivo)

		TRA	TRAT1
Gene Name		T cell receptor alpha locus	T cell receptor associated transmembrane adaptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Plasma Membrane Integral Component Of Plasma Membrane T Cell Receptor Complex
	Molecular Function		Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
	Biological Process		Negative Regulation Of Receptor Recycling Cellular Defense Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport
Pathways			Signaling by the B Cell Receptor (BCR) Downstream TCR signaling Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR TCR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065)
Protein-Protein Interactions		15 interactors: CANX CD247 CD3D CD3G HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD UBC	11 interactors: CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SRC TRA TRB
Entrez ID		6955	50852
HPRD ID		01736	05392
Ensembl ID			ENSG00000163519
Uniprot IDs			Q6PIZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune System Process Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Peptide Antigen T Cell Costimulation Innate Immune Response Positive Regulation Of T Cell Activation Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Detection Of Bacterium Antigen Processing And Presentation Cellular Response To Cytokine Stimulus Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Cell Activation Signaling Detection Of Biotic Stimulus Cell Communication Regulation Of Cell Adhesion Response To Cytokine Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Lymphocyte Activation Defense Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Signal Transduction Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Interferon-gamma-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Response To Stress Fc Receptor Signaling Pathway Response To Organic Substance Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Organic Substance Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Cellular Response To Stimulus	T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Platelet Activation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell Adhesion Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Innate Immune Response Blood Coagulation Hemostasis Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Viral Process Phagocytosis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune System Process Response To Wounding Immune Response Peptidyl-tyrosine Autophosphorylation Defense Response Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		activates adenocarcinoma agonists analogs beneficial cd du eliminate exhibits far indiscriminate inducing knockout morphogenesis natural possibly prostate rar rars retinoic retinoid retinoids reverses rxrs selective selectively synthetic undermined undesirable
Tagcloud (Difference) ?		activates adenocarcinoma agonists analogs beneficial cd du eliminate exhibits far indiscriminate inducing knockout morphogenesis natural possibly prostate rar rars retinoic retinoid retinoids reverses rxrs selective selectively synthetic undermined undesirable
Tagcloud (Intersection) ?