IBTK and LAMTOR3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IBTK	LAMTOR3
Description		inhibitor of Bruton tyrosine kinase	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Cytoplasm Lysosomal Membrane Endosome Late Endosome Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol	Intracellular Protein Localization Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling
Pathways			Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 31798171) Corneal resistance factor ( 32716492) Corneal structure ( 23291589) Coronary artery disease ( 33020668) Intraocular pressure ( 29235454 29617998)	Mean reticulocyte volume ( 32888494)
Interacting Genes		6 interacting genes: BTK LAMTOR3 PDCD4 PPP1CA PRKCB PRKD1	20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4
Entrez ID		25998	8649
HPRD ID		12105	04485
Ensembl ID		ENSG00000005700	ENSG00000109270
Uniprot IDs		B7ZLE0 E7EPI0 Q9P2D0	Q9UHA4
PDB IDs			1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cellular Response To Oxygen-containing Compound Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cell Death Regulation Of Intracellular Signal Transduction Regulation Of NLRP3 Inflammasome Complex Assembly Protein Kinase C Binding B Cell Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Protein Kinase Activity Positive Regulation Of Type I Hypersensitivity Regulation Of Hormone Levels Positive Regulation Of DNA-binding Transcription Factor Activity Phosphate-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport B Cell Affinity Maturation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Histone H3T6 Kinase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Kinase Activity Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Hormone Secretion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Synoviocyte Proliferation	Regulation Of Golgi Inheritance Regulation Of Golgi Organization Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Animal Organ Formation Face Development ERBB2 Signaling Pathway Lung Morphogenesis Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Thymus Development ERK1 And ERK2 Cascade Late Endosome Glial Cell Development ERBB Signaling Pathway Myelination Interleukin-34-mediated Signaling Pathway Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Astrocyte Differentiation Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Outer Ear Morphogenesis Molecular Adaptor Activity Regulation Of MAPK Cascade MAP-kinase Scaffold Activity MAPK Cascade MAP Kinase Kinase Activity MAP Kinase Activity Pseudopodium Regulation Of DNA-templated Transcription Gland Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Macrophage Chemotaxis Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Regulation Of Cellular Localization Regulation Of Cellular Response To Stress Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytoplasm
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