IBTK

Description		inhibitor of Bruton tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol
Pathways
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 31798171) Corneal resistance factor ( 32716492) Corneal structure ( 23291589) Coronary artery disease ( 33020668) Intraocular pressure ( 29235454 29617998)
Interacting Genes		6 interacting genes: BTK LAMTOR3 PDCD4 PPP1CA PRKCB PRKD1
Entrez ID		25998
HPRD ID		12105
Ensembl ID		ENSG00000005700
Uniprot IDs		B7ZLE0 E7EPI0 Q9P2D0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cellular Response To Oxygen-containing Compound Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cell Death Regulation Of Intracellular Signal Transduction Regulation Of NLRP3 Inflammasome Complex Assembly Protein Kinase C Binding B Cell Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Protein Kinase Activity Positive Regulation Of Type I Hypersensitivity Regulation Of Hormone Levels Positive Regulation Of DNA-binding Transcription Factor Activity Phosphate-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport B Cell Affinity Maturation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Histone H3T6 Kinase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Kinase Activity Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Hormone Secretion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Synoviocyte Proliferation
Tagcloud ?