IBTK and PRKD1

Number of citations of the paper that reports this interaction (PMID 21482705)
2

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		IBTK	PRKD1
Gene Name		inhibitor of Bruton agammaglobulinemia tyrosine kinase	protein kinase D1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane	Nucleus Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Tyrosine Kinase Activity	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Sphingolipid Metabolic Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Cell Proliferation Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Corneal structure ( 23291589)	Body mass index ( 23669352 20935630) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: BTK LAMTOR3 PPP1CA PRKCB PRKD1	31 interactors: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 GNB2L1 HDAC5 HDAC7 HSPB1 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A PLCG1 PLCG2 PPP1R14A PRKCE PRKCH SRC SYK TP53 YWHAQ YWHAZ
Entrez ID		25998	5587
HPRD ID		12105	05668
Ensembl ID		ENSG00000005700	ENSG00000184304
Uniprot IDs		Q9P2D0	F8WBA3 Q15139
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity B Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of B Cell Cytokine Production Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Angiogenesis Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Kinase D Signaling Cellular Response To Molecule Of Fungal Origin Histone H3-T6 Phosphorylation B Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Histone Deacetylase Activity Peptidyl-amino Acid Modification Apoptotic Process Cellular Response To Oxidative Stress Programmed Cell Death Protein Autophosphorylation Response To Molecule Of Fungal Origin Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Death Death Regulation Of Angiogenesis Regulation Of Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Phosphate-containing Compound Metabolic Process Positive Regulation Of Deacetylase Activity Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Protein Phosphorylation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Glycogen Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Death Histamine Secretion By Mast Cell Negative Regulation Of Transport	Fc Receptor Signaling Pathway Cell Activation Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Defense Response Enzyme Linked Receptor Protein Signaling Pathway Signaling Regulation Of Signaling Blood Coagulation Hemostasis Cell Communication Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organic Substance Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Transport Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Stimulus Response To Growth Factor Programmed Cell Death Wound Healing Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Cellular Response To Organic Substance Cell Death Death Regulation Of Cell Motility Positive Regulation Of Metabolic Process Positive Regulation Of Immune Response Response To Stress
Tagcloud ?			adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?			adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?