IBTK and PRKD1

Number of citations of the paper that reports this interaction (PubMedID 21482705)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		IBTK	PRKD1
Description		inhibitor of Bruton tyrosine kinase	protein kinase D1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Autophagosome Membrane Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Cell Cortex Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Immune System Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Sphingolipid Biosynthetic Process Cell Differentiation Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Sarcomere Organization Transepithelial Transport Cellular Response To Hydroperoxide Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Endothelin Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway
Pathways			Sphingolipid de novo biosynthesis
Drugs			Bryostatin 1 Fostamatinib
Diseases
GWAS		Central corneal thickness ( 29760442 31798171) Corneal resistance factor ( 32716492) Corneal structure ( 23291589) Coronary artery disease ( 33020668) Intraocular pressure ( 29235454 29617998)	Academic attainment (English) ( 33594131) Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 23669352 25673413 28552196 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) California verbal learning test score ( 31596458) Carotid plaque burden ( 28282560) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood body mass index ( 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) IgM levels ( 28628107) Intelligence (MTAG) ( 29326435) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Schizophrenia ( 30285260 29483656 25056061 34099189) Spatial processing ( 31596458) Systolic blood pressure ( 30224653) Type 2 diabetes ( 30130595) Urinary sodium excretion ( 31409800) Waist circumference ( 28552196 25673412) Weight ( 28552196)
Interacting Genes		6 interacting genes: BTK LAMTOR3 PDCD4 PPP1CA PRKCB PRKD1	33 interacting genes: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 HDAC5 HDAC7 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A NOS1 PLCG1 PLCG2 PPP1R14A PRKCE PRKCH RACK1 SPRY2 SRC SYK TFAP2A TP53 USP28 YWHAQ
Entrez ID		25998	5587
HPRD ID		12105	05668
Ensembl ID		ENSG00000005700	ENSG00000184304
Uniprot IDs		B7ZLE0 E7EPI0 Q9P2D0	F8WBA3 Q15139
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cellular Response To Oxygen-containing Compound Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cell Death Regulation Of Intracellular Signal Transduction Regulation Of NLRP3 Inflammasome Complex Assembly Protein Kinase C Binding B Cell Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Protein Kinase Activity Positive Regulation Of Type I Hypersensitivity Regulation Of Hormone Levels Positive Regulation Of DNA-binding Transcription Factor Activity Phosphate-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport B Cell Affinity Maturation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Histone H3T6 Kinase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Kinase Activity Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Hormone Secretion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Synoviocyte Proliferation	Intracellular Signaling Cassette Fc Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Enzyme Binding Signal Transduction Regulation Of Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Post-translational Protein Modification Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase C Binding Response To Lipid Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Cell Activation Regulation Of Protein Neddylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Motility Cellular Response To Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Locomotion Positive Regulation Of Programmed Cell Death
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