IBTK and PDCD4

Number of citations of the paper that reports this interaction (PubMedID 25882842)
50

Data Source:
BioGRID (pull down)

		IBTK	PDCD4
Description		inhibitor of Bruton tyrosine kinase	programmed cell death 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol	Apoptotic Process BMP Signaling Pathway Negative Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 31798171) Corneal resistance factor ( 32716492) Corneal structure ( 23291589) Coronary artery disease ( 33020668) Intraocular pressure ( 29235454 29617998)	Fish- and plant-related diet ( 32066663)
Interacting Genes		6 interacting genes: BTK LAMTOR3 PDCD4 PPP1CA PRKCB PRKD1	21 interacting genes: APOE BTRC CSNK2A1 EIF4A1 EIF4A2 EIF4A3 EIF4G1 FILNC1 IBTK LRRK1 OGT PRMT5 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2 WDR77
Entrez ID		25998	27250
HPRD ID		12105	10549
Ensembl ID		ENSG00000005700	ENSG00000150593
Uniprot IDs		B7ZLE0 E7EPI0 Q9P2D0	B4DKX4 Q53EL6
PDB IDs			2GGF 2KZT 2RG8 2ZU6 3EIJ 8XXL 8XXM 8XXN 9BKD 9BLN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cellular Response To Oxygen-containing Compound Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cell Death Regulation Of Intracellular Signal Transduction Regulation Of NLRP3 Inflammasome Complex Assembly Protein Kinase C Binding B Cell Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Protein Kinase Activity Positive Regulation Of Type I Hypersensitivity Regulation Of Hormone Levels Positive Regulation Of DNA-binding Transcription Factor Activity Phosphate-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport B Cell Affinity Maturation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Histone H3T6 Kinase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Kinase Activity Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Hormone Secretion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Synoviocyte Proliferation	Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Translation Regulation Of Primary Metabolic Process Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Translational Initiation Cytoplasmic Translational Initiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Translation Ribonucleoprotein Complex Binding Negative Regulation Of Macromolecule Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteolysis Translation Initiation Factor Activity Gamma-secretase Complex Negative Regulation Of Metabolic Process Positive Regulation Of Translation Regulation Of Wnt Signaling Pathway Negative Regulation Of Gene Expression Notch Receptor Processing Glutamatergic Synapse Amyloid-beta Formation Epithelial Cell Proliferation TORC1 Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction
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