HR and CNFN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HR	CNFN
Description		HR lysine demethylase and nuclear receptor corepressor	cornifelin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Nuclear Body	Cornified Envelope Cytoplasm
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Histone H3K9me/H3K9me2 Demethylase Activity	Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Keratinization
Pathways
Drugs
Diseases		Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH) Atrichia with papular lesions
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		35 interacting genes: ACTMAP AMMECR1 ATP23 CFAP68 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12	16 interacting genes: CCDC120 CREB5 EVX2 FAM222B HOXA1 HOXB5 HR KPRP SLC12A4 TCF7L2 TFAP2D TLE5 VGLL3 WDR25 ZNF414 ZNF581
Entrez ID		55806	84518
HPRD ID		03808	16729
Ensembl ID		ENSG00000168453	ENSG00000105427
Uniprot IDs		O43593	Q9BYD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Activity, Hydrolytic Mechanism Intermediate Filament Histone Deacetylase Complex Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Transcription Repressor Complex Protein Lysine Delactylase Activity Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Glandular Epithelial Cell Development Keratin Filament Cardiac Muscle Cell Differentiation Negative Regulation Of Cytokine Production Ventricular Cardiac Muscle Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Heterocyclic Compound Binding Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Cardiocyte Differentiation Transcription Corepressor Binding Histone Deacetylase Binding Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Growth Plate Cartilage Development Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Protein Deacetylation Positive Regulation Of RNA Biosynthetic Process Hippocampus Development Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Striated Muscle Cell Differentiation Columnar/cuboidal Epithelial Cell Development Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Structural Molecule Activity Nuclear Retinoid X Receptor Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Regulation Of Striated Muscle Cell Differentiation Apoptotic Cell Clearance	DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Semicircular Canal Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Abducens Nerve Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Optokinetic Behavior Inferior Colliculus Development Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Myoblast Fate Commitment
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