HR and KLHL20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HR	KLHL20
Description		HR lysine demethylase and nuclear receptor corepressor	kelch like family member 20
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Nuclear Body	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Histone H3K9me/H3K9me2 Demethylase Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH) Atrichia with papular lesions
GWAS		Obesity-related traits ( 23251661)	Feeling miserable ( 29500382)
Interacting Genes		35 interacting genes: ACTMAP AMMECR1 ATP23 CFAP68 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12	81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT
Entrez ID		55806	27252
HPRD ID		03808	13918
Ensembl ID		ENSG00000168453	ENSG00000076321
Uniprot IDs		O43593	Q9Y2M5
PDB IDs			5YQ4 6GY5 8CIA
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Activity, Hydrolytic Mechanism Intermediate Filament Histone Deacetylase Complex Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Transcription Repressor Complex Protein Lysine Delactylase Activity Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Glandular Epithelial Cell Development Keratin Filament Cardiac Muscle Cell Differentiation Negative Regulation Of Cytokine Production Ventricular Cardiac Muscle Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Heterocyclic Compound Binding Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Cardiocyte Differentiation Transcription Corepressor Binding Histone Deacetylase Binding Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Growth Plate Cartilage Development Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Protein Deacetylation Positive Regulation Of RNA Biosynthetic Process Hippocampus Development Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Striated Muscle Cell Differentiation Columnar/cuboidal Epithelial Cell Development Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Structural Molecule Activity Nuclear Retinoid X Receptor Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Regulation Of Striated Muscle Cell Differentiation Apoptotic Cell Clearance	Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I
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