HR and RARB

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		HR	RARB
Description		HR lysine demethylase and nuclear receptor corepressor	retinoic acid receptor beta
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Nuclear Body	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Histone H3K9me/H3K9me2 Demethylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Apoptotic Process Signal Transduction Cell Population Proliferation Programmed Cell Death Striatum Development Neurogenesis Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Bone Development Negative Regulation Of Cartilage Development Neural Precursor Cell Proliferation Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation
Pathways			Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550 Trifarotene
Diseases		Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH) Atrichia with papular lesions	Small cell lung cancer Non-small cell lung cancer
GWAS		Obesity-related traits ( 23251661)	Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Airflow obstruction ( 22837378) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Apolipoprotein A1 levels ( 32203549) Asthma ( 29273806) Bell's palsy ( 33602968) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28448500 28892062 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Calcium levels ( 25972035) Carotid intima media thickness in rheumatoid arthritis ( 30251476) Cataracts ( 34127677) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronotype ( 30696823) Coffee consumption ( 31046077) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Dentures ( 31235808) Dietary macronutrient intake ( 29988085) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 29891935 33627673) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29785010 31959993) Low susceptibility to hepatitis C infection ( 31206233) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Molybdenum levels ( 26025379) Mood instability ( 31168069) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity (extreme) ( 19553259) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Optic disc area ( 31798171 28073927 25631615) Optic disc size ( 31809533) Optic nerve head parameters (multi-trait analysis) ( 31798171) Peak expiratory flow ( 30804560) Platelet distribution width ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		35 interacting genes: ACTMAP AMMECR1 ATP23 CFAP68 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12	24 interacting genes: ARID1A CCNDBP1 CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 NRIP1 PNRC1 PPARGC1A PRKD2 PSMC5 RSPH1 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1
Entrez ID		55806	5915
HPRD ID		03808	07183
Ensembl ID		ENSG00000168453	ENSG00000077092
Uniprot IDs		O43593	A0A8I5KWP3 F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5
PDB IDs			1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Activity, Hydrolytic Mechanism Intermediate Filament Histone Deacetylase Complex Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Transcription Repressor Complex Protein Lysine Delactylase Activity Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Glandular Epithelial Cell Development Keratin Filament Cardiac Muscle Cell Differentiation Negative Regulation Of Cytokine Production Ventricular Cardiac Muscle Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Heterocyclic Compound Binding Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Cardiocyte Differentiation Transcription Corepressor Binding Histone Deacetylase Binding Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Growth Plate Cartilage Development Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Protein Deacetylation Positive Regulation Of RNA Biosynthetic Process Hippocampus Development Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Striated Muscle Cell Differentiation Columnar/cuboidal Epithelial Cell Development Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Structural Molecule Activity Nuclear Retinoid X Receptor Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Regulation Of Striated Muscle Cell Differentiation Apoptotic Cell Clearance	Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Retinoic Acid Receptor Signaling Pathway Regulation Of Primary Metabolic Process DNA-templated Transcription Retinoic Acid-responsive Element Binding DNA Binding Transcription Coactivator Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Chromatin DNA Binding Sequence-specific DNA Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Response To Lipid Nuclear Glucocorticoid Receptor Binding Brahma Complex Transcription Coregulator Activity NpBAF Complex Regulation Of Multicellular Organismal Development NBAF Complex Nuclear Retinoic Acid Receptor Binding Nucleobase-containing Compound Biosynthetic Process Hormone-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding C/EBP Complex DNA-binding Transcription Factor Activity Nucleosome Disassembly
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