TAFAZZIN and CHGB

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		TAFAZZIN	CHGB
Name		tafazzin, phospholipid-lysophospholipid transacylase	chromogranin B
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Transferase Activity Acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity	Hormone Activity Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inner Mitochondrial Membrane Organization Cardiolipin Acyl-chain Remodeling Cristae Formation Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process	Signal Transduction
Pathways		Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Diseases		Dilated cardiomyopathy (DCM) Barth syndrome (BTHS) 3-Methylglutaconic aciduria (MGCA)	None
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 ) Uterine fibroid number (single vs multiple) ( 30196971 )
Interacting Genes		12 interacting genes: BTRC CFTR CHGB CSNK1E GSK3B LATS2 NHERF2 NONO RUNX1 USP14 USP26 YWHAE	34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAFAZZIN TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1
Entrez ID		6901	1114
HPRD ID		02316	07512
Ensembl ID		ENSG00000102125	ENSG00000089199
Uniprot IDs		A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A6XNE1 Q16635	P05060
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Wnt Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Rhythmic Process Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Negative Regulation Of Protein Catabolic Process Deubiquitinase Activity Negative Regulation Of Protein Metabolic Process Hippo Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Rhythm Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Microtubule Anchoring At Centrosome Creatine:sodium Symporter Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Hippo Signaling Protein Modification Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Proteolysis Non-canonical Wnt Signaling Pathway Negative Regulation Of Metabolic Process	Nucleotide Binding Cytoplasm Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Manganese Ion Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential GTP Binding Leukocyte Aggregation RAGE Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Manganese Ion Identical Protein Binding Regulation Of Developmental Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Golgi-associated Vesicle Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Catecholamine Stimulus Positive Regulation Of Proteolysis Response To Catecholamine Developmental Maturation ATP Binding Protein Tetramerization Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Membrane Organization Extracellular Exosome Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Defense Response Growth Cone Lamellipodium Regulation Of Growth Regulation Of Cell Projection Organization Regulation Of Cell Activation Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Amylin Binding