TAFAZZIN and RPL10

Data Source: HiPPIP (Novel)

		TAFAZZIN	RPL10
Name		tafazzin, phospholipid-lysophospholipid transacylase	ribosomal protein L10
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Transferase Activity Acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding Translation Regulator Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inner Mitochondrial Membrane Organization Cardiolipin Acyl-chain Remodeling Cristae Formation Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Cytoplasmic Translation Translation Regulation Of Translation Negative Regulation Of Apoptotic Process Embryonic Brain Development
Pathways		Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		None	Artenimol
Diseases		Dilated cardiomyopathy (DCM) Barth syndrome (BTHS) 3-Methylglutaconic aciduria (MGCA)	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		12 interacting genes: BTRC CFTR CHGB CSNK1E GSK3B LATS2 NHERF2 NONO RUNX1 USP14 USP26 YWHAE	15 interacting genes: DUX4 ERCC6 FYN HCK LYN MAPK6 OGT PRKCA PTEN RAD21 SRC SUMO2 TAB1 TBPL1 YES1
Entrez ID		6901	6134
HPRD ID		02316	02421
Ensembl ID		ENSG00000102125	ENSG00000147403
Uniprot IDs		A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A6XNE1 Q16635	P27635 X5D2T3
PDB IDs		Not available	2PA2 5AJ0 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6W6L 7F5S 7XNX 7XNY 8A3D 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8K2C 8QFD 8XSY 8XSZ 8YOO 8YOP 9C3H 9GMO
GO Terms Enriched among Interactors		Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Wnt Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Rhythmic Process Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Negative Regulation Of Protein Catabolic Process Deubiquitinase Activity Negative Regulation Of Protein Metabolic Process Hippo Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Rhythm Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Microtubule Anchoring At Centrosome Creatine:sodium Symporter Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Hippo Signaling Protein Modification Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Proteolysis Non-canonical Wnt Signaling Pathway Negative Regulation Of Metabolic Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway Protein Modification Process T Cell Costimulation Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Protein Phosphorylation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response Immune Response-activating Signaling Pathway Intracellular Signal Transduction Kinase Activity Stimulatory C-type Lectin Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Phosphorylation Cellular Response To Lectin Signaling Receptor Binding Cellular Response To Platelet-derived Growth Factor Stimulus Enzyme Binding Activation Of Innate Immune Response Actin Filament Negative Regulation Of Immune Response Immune Response-regulating Signaling Pathway Response To Platelet-derived Growth Factor Activation Of Immune Response Leukocyte Migration Ephrin Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Protein Metabolic Process Transferase Activity Positive Regulation Of Innate Immune Response Response To Peptide Hormone Transmembrane Transporter Binding Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Response To Reactive Oxygen Species