CHGB and PRAG1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)

		CHGB	PRAG1
Description		chromogranin B	PEAK1 related, kinase-activating pseudokinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule	Nucleus Cytoplasm Cytosol Focal Adhesion Anchoring Junction
	Molecular Function	Hormone Activity Protein Binding	Protein Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Signal Transduction	Regulation Of Cell Shape Regulation Of Notch Signaling Pathway Negative Regulation Of Neuron Projection Development Cell Migration Positive Regulation Of Rho Protein Signal Transduction Regulation Of Cell Motility
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	RND2 GTPase cycle
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Uterine fibroid number (single vs multiple) ( 30196971)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Processed meat consumption ( 32066663) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid stimulating hormone levels ( 32769997) TPE interval (resting) ( 32386560)
Interacting Genes		34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAFAZZIN TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	3 interacting genes: CHGB PSAP UBE3A
Entrez ID		1114	157285
HPRD ID		07512	19497
Ensembl ID		ENSG00000089199	ENSG00000275342
Uniprot IDs		P05060	Q86YV5
PDB IDs			5VE6 8DGN
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Cytoplasm Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Manganese Ion Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential GTP Binding Leukocyte Aggregation RAGE Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Manganese Ion Identical Protein Binding Regulation Of Developmental Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Golgi-associated Vesicle Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Catecholamine Stimulus Positive Regulation Of Proteolysis Response To Catecholamine Developmental Maturation ATP Binding Protein Tetramerization Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Membrane Organization Extracellular Exosome Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Defense Response Growth Cone Lamellipodium Regulation Of Growth Regulation Of Cell Projection Organization Regulation Of Cell Activation Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Amylin Binding	Prostate Gland Growth Organ Growth Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Sperm Entry Positive Regulation Of Golgi Lumen Acidification Ganglioside GT1b Binding Ganglioside GM1 Binding Regulation Of Golgi Lumen Acidification Positive Regulation Of Cellular PH Reduction Positive Regulation Of Protein Localization To Lysosome Developmental Growth Glycolipid Transport Epithelial Cell Differentiation Involved In Prostate Gland Development Progesterone Receptor Signaling Pathway Ceramide Transport Androgen Receptor Signaling Pathway Postsynaptic Cytosol
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