CHGB and MARK3

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		CHGB	MARK3
Name		chromogranin B	microtubule affinity regulating kinase 3
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome
	Molecular Function	Hormone Activity Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction	Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		None	Fostamatinib
GWAS		Metabolite levels ( 23823483 ) Uterine fibroid number (single vs multiple) ( 30196971 )	Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Blond vs. brown/black hair color ( 30531825 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 33020668 ) Cutaneous melanoma or hair colour ( 32341527 ) Femoral neck bone mineral density ( 22504420 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 29403010 27863252 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Optic disc size ( 31809533 ) PR interval ( 32439900 ) Systolic blood pressure ( 30578418 30224653 ) Type 2 diabetes ( 30297969 ) White blood cell count ( 32888494 )
Novel Interactors		None recorded	5 novel interactors: CDC42BPB HMOX2 RCOR3 RECQL SLC27A4
Interacting Genes		34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAFAZZIN TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	28 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAZ
Entrez ID		1114	4140
HPRD ID		07512	04058
Ensembl ID		ENSG00000089199	ENSG00000075413
Uniprot IDs		P05060	A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11
PDB IDs		Not available	2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL
GO Terms Enriched among Interactors		Nucleotide Binding Cytoplasm Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Manganese Ion Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential GTP Binding Leukocyte Aggregation RAGE Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Manganese Ion Identical Protein Binding Regulation Of Developmental Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Golgi-associated Vesicle Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Catecholamine Stimulus Positive Regulation Of Proteolysis Response To Catecholamine Developmental Maturation ATP Binding Protein Tetramerization Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Membrane Organization Extracellular Exosome Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Defense Response Growth Cone Lamellipodium Regulation Of Growth Regulation Of Cell Projection Organization Regulation Of Cell Activation Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Amylin Binding	Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule