TAFAZZIN and TRAK2

Data Source: HiPPIP (Novel)

		TAFAZZIN	TRAK2
Name		tafazzin, phospholipid-lysophospholipid transacylase	trafficking kinesin protein 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane	Nucleus Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Plasma Membrane Dendrite Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Axonal Growth Cone
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Transferase Activity Acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity	Signaling Receptor Binding Protein Binding Myosin Binding Kinesin Binding Enzyme Binding TPR Domain Binding GABA Receptor Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inner Mitochondrial Membrane Organization Cardiolipin Acyl-chain Remodeling Cristae Formation Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Negative Regulation Of Axonogenesis Dendritic Transport Of Mitochondrion
Pathways		Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL	RHOT2 GTPase cycle RHOT1 GTPase cycle
Diseases		Dilated cardiomyopathy (DCM) Barth syndrome (BTHS) 3-Methylglutaconic aciduria (MGCA)	None
GWAS		No GWAS studies recorded	Breast cancer ( 31757997 ) Cocaine use disorder x change in residence interaction ( 31490055 )
Novel Interactors		7 novel interactors: CCDC88C OPN1LW RPL10 SLC6A8 SSR4 TRAK2 VBP1	2 novel interactors: NIF3L1 TAFAZZIN
Interacting Genes		12 interacting genes: BTRC CFTR CHGB CSNK1E GSK3B LATS2 NHERF2 NONO RUNX1 USP14 USP26 YWHAE	4 interacting genes: EIF4ENIF1 GABRB2 KCNJ2 OGT
Entrez ID		6901	66008
HPRD ID		02316	09547
Ensembl ID		ENSG00000102125	ENSG00000115993
Uniprot IDs		A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A6XNE1 Q16635	O60296
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Wnt Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Rhythmic Process Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Negative Regulation Of Protein Catabolic Process Deubiquitinase Activity Negative Regulation Of Protein Metabolic Process Hippo Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Rhythm Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Microtubule Anchoring At Centrosome Creatine:sodium Symporter Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Hippo Signaling Protein Modification Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Proteolysis Non-canonical Wnt Signaling Pathway Negative Regulation Of Metabolic Process	Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Relaxation Of Skeletal Muscle Positive Regulation Of Cardiolipin Metabolic Process Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA GABA Receptor Activity Dendritic Spine Cellular Response To Histamine Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Positive Regulation Of Lipid Metabolic Process Regulation Of Cardiolipin Metabolic Process Mitochondrial Membrane Cardiolipin Acyl-chain Remodeling 1-acylglycerophosphocholine O-acyltransferase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translation Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Carbon Catabolite Regulation Of Transcription Postsynaptic Membrane