CHGB and MFHAS1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		CHGB	MFHAS1
Description		chromogranin B	multifunctional ROCO family signaling regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule	Cytoplasm Mitochondrion Lysosome Cytoskeleton
	Molecular Function	Hormone Activity Protein Binding	Nucleotide Binding Protein Binding GTP Binding Ubiquitin Protein Ligase Binding Protein Phosphatase 2A Binding
	Biological Process	Signal Transduction	Immune System Process Defense Response Inflammatory Response Negative Regulation Of Signal Transduction Erythrocyte Differentiation Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Uterine fibroid number (single vs multiple) ( 30196971)	A body shape index ( 34021172) Acne (severe) ( 24927181) Adventurousness ( 30643258) Age at first sexual intercourse ( 27089180) Aspartate aminotransferase levels ( 33547301) Bipolar disorder (early vs late onset) ( 34016946) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cooked vegetable consumption ( 32066663) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 29187730) Neuroticism ( 29255261) Processed meat consumption ( 32066663) Refractive error ( 32231278) Skin aging (microtopography measurement) ( 28502801) Systemic lupus erythematosus ( 28714469) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAFAZZIN TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	88 interacting genes: ABLIM1 AGFG1 AHCYL1 AHDC1 ANKRD13A ANKRD13D ANKS4B APEX2 AURKB BAG2 CABP4 CALM1 CALML3 CALU CAPRIN1 CBLB CCDC149 CCDC43 CDC42EP3 CEBPZ CEP85 CETN3 CHGB CLK1 COPB2 CRTC2 CUEDC1 CYREN DDI1 DRC3 E2F4 EGLN2 ESRRG ETV5 FGF16 FGFR1 FOXN3 GAK GAS2L3 GPBP1L1 GSDMD GTSF1 HIC2 IFTAP KLHDC4 LIMA1 LIMK1 MAP3K4 MRGBP NEK1 NEK11 PDCL PGRMC2 PJA2 PMM1 POLA2 POLI PPARG PRKAG2 PSME3IP1 RASL11B RCN2 RHBDD1 ROR1 RPAP3 RTKN SELENOS SH2D2A SLC4A1AP SMTNL2 SNAI1 STK25 STN1 STUB1 SUPT4H1 TADA3 TAS2R60 TBC1D22B TOX2 TRAPPC2 TRIM22 TTC27 UBL7 VGLL4 VN1R1 WWTR1 ZFAND5 ZMYM5
Entrez ID		1114	9258
HPRD ID		07512	12010
Ensembl ID		ENSG00000089199	ENSG00000147324
Uniprot IDs		P05060	Q9Y4C4
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Cytoplasm Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Manganese Ion Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential GTP Binding Leukocyte Aggregation RAGE Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Manganese Ion Identical Protein Binding Regulation Of Developmental Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Golgi-associated Vesicle Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Catecholamine Stimulus Positive Regulation Of Proteolysis Response To Catecholamine Developmental Maturation ATP Binding Protein Tetramerization Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Membrane Organization Extracellular Exosome Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Defense Response Growth Cone Lamellipodium Regulation Of Growth Regulation Of Cell Projection Organization Regulation Of Cell Activation Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Amylin Binding
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