CHGB and PKN2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CHGB	PKN2
Gene Name		chromogranin B (secretogranin 1)	protein kinase N2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Secretory Granule	Nucleus Nucleoplasm Cytoplasm Centrosome Plasma Membrane Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Hormone Activity Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Histone Deacetylase Binding Poly(A) RNA Binding RNA Polymerase Binding
	Biological Process		Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Positive Regulation Of Cytokinesis Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility
Pathways
Drugs
Diseases
GWAS			Height ( 20881960) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		31 interactors: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 MARK3 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SGK223 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	17 interactors: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA
Entrez ID		1114	5586
HPRD ID		07512	03972
Ensembl ID		ENSG00000089199	ENSG00000065243
Uniprot IDs		P05060	Q16513
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Developmental Growth Cellular Metabolic Process Cellular Component Assembly Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Cell Differentiation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Synaptic Transmission Response To Metal Ion Response To Lipid Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cell Development Generation Of Neurons Response To Growth Factor Phosphate-containing Compound Metabolic Process Response To Organic Cyclic Compound Protein Homotetramerization Platelet Activation Positive Regulation Of Metabolic Process Response To Stress Metabolic Process Neurogenesis Response To Organic Substance Positive Regulation Of Lamellipodium Assembly Cellular Process Apoptotic Process Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Defense Response Hemostasis DNA-templated Transcription, Initiation Negative Regulation Of Developmental Growth Response To Wounding Long Term Synaptic Depression Programmed Cell Death Regulation Of Neurogenesis Nucleotide-excision Repair Positive Regulation Of Lamellipodium Organization Negative Regulation Of Growth Cell Death Death Cell Development Regulation Of Protein Import Into Nucleus, Translocation Developmental Process Regulation Of Cell Morphogenesis Response To Inorganic Substance	Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Kinase Activity Cell Development Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Regulation Of Endothelial Cell Migration Regulation Of T Cell Activation Cellular Response To Growth Factor Stimulus Immune System Process Regulation Of Protein Metabolic Process Response To Growth Factor Negative Regulation Of Protein Phosphorylation Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Epithelial Cell Migration Cell Projection Organization Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Lamellipodium Organization Locomotion Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cell Motility Negative Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell-cell Adhesion
Tagcloud ?		adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von	abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine
Tagcloud (Difference) ?		adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von	abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine
Tagcloud (Intersection) ?