CHGB and PKN2

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		CHGB	PKN2
Name		chromogranin B	protein kinase N2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Cell Projection Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Hormone Activity Protein Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction	Protein Phosphorylation Apoptotic Process Cell Adhesion Signal Transduction Epithelial Cell Migration Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Motility
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		None	Fostamatinib
GWAS		Metabolite levels ( 23823483 ) Uterine fibroid number (single vs multiple) ( 30196971 )	Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 34315874 33547301 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 27841878 ) General risk tolerance (MTAG) ( 30643258 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 25282103 31562340 20881960 ) Intraocular pressure ( 29617998 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514 ) Narcolepsy ( 23459209 ) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Periodontal microbiota ( 22699663 ) Photic sneeze reflex ( 27182965 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Response to fenofibrate (LDL cholesterol levels) ( 27002377 ) Rosacea symptom severity ( 29771307 ) Serum protein levels (sST2) ( 23999434 ) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306 ) Systolic blood pressure ( 27841878 30224653 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for body mass index ( 34021172 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )
Interacting Genes		34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAFAZZIN TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA RNF10 SUMO2
Entrez ID		1114	5586
HPRD ID		07512	03972
Ensembl ID		ENSG00000089199	ENSG00000065243
Uniprot IDs		P05060	Q16513
PDB IDs		Not available	4CRS 4RRV 6CCY 6GBE
GO Terms Enriched among Interactors		Nucleotide Binding Cytoplasm Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Manganese Ion Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential GTP Binding Leukocyte Aggregation RAGE Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Manganese Ion Identical Protein Binding Regulation Of Developmental Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Golgi-associated Vesicle Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Catecholamine Stimulus Positive Regulation Of Proteolysis Response To Catecholamine Developmental Maturation ATP Binding Protein Tetramerization Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Membrane Organization Extracellular Exosome Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Defense Response Growth Cone Lamellipodium Regulation Of Growth Regulation Of Cell Projection Organization Regulation Of Cell Activation Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Amylin Binding	Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response ERBB Signaling Pathway Lamellipodium Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of T Cell Activation Roundabout Signaling Pathway Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Lamellipodium Organization Regulation Of Lymphocyte Activation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Stress Glutamatergic Synapse Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Population Proliferation Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Cell Cortex Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cell Activation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interleukin-18-mediated Signaling Pathway Immune System Process Vascular Endothelial Cell Response To Fluid Shear Stress Protein Kinase Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Laminar Fluid Shear Stress Cellular Response To Insulin Stimulus Ruffle Membrane Regulation Of Cell Adhesion