TAFAZZIN and OPN1LW

		TAFAZZIN	OPN1LW
Description		tafazzin, phospholipid-lysophospholipid transacylase	opsin 1, long wave sensitive
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Transferase Activity Acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inner Mitochondrial Membrane Organization Cardiolipin Acyl-chain Remodeling Cristae Formation Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Detection Of Visible Light Absorption Of Visible Light Positive Regulation Of Cytokinesis Cellular Response To Light Stimulus
Pathways		Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL	The retinoid cycle in cones (daylight vision) G alpha (i) signalling events Opsins Defective visual phototransduction due to OPN1LW loss of function
Drugs
Diseases		Dilated cardiomyopathy (DCM) Barth syndrome (BTHS) 3-Methylglutaconic aciduria (MGCA)	Blue cone monochromacy Colorblindness, including: Dichromacy; Anomalous trichromacy
GWAS			Lymphocyte count ( 32888494)
Interacting Genes		12 interacting genes: BTRC CFTR CHGB CSNK1E GSK3B LATS2 NHERF2 NONO RUNX1 USP14 USP26 YWHAE	6 interacting genes: NCOA2 NRM PIAS3 RANBP2 TICAM2 TRARG1
Entrez ID		6901	5956
HPRD ID		02316	02366
Ensembl ID		ENSG00000102125	ENSG00000102076
Uniprot IDs		A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A6XNE1 Q16635	P04000
PDB IDs			8IU2
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Wnt Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Rhythmic Process Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Negative Regulation Of Protein Catabolic Process Deubiquitinase Activity Negative Regulation Of Protein Metabolic Process Hippo Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Rhythm Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Microtubule Anchoring At Centrosome Creatine:sodium Symporter Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Hippo Signaling Protein Modification Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Proteolysis Non-canonical Wnt Signaling Pathway Negative Regulation Of Metabolic Process	SUMO Ligase Activity SUMO Transferase Activity Toll-like Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Protein Sumoylation Innate Immune Response-activating Signaling Pathway Annulate Lamellae Negative Regulation Of Immune System Process Cytoplasmic Periphery Of The Nuclear Pore Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Export From Nucleus SUMO Ligase Complex Regulation Of Glucose Metabolic Process Nuclear Pore Cytoplasmic Filaments Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling 1-acylglycerophosphocholine O-acyltransferase Activity Positive Regulation Of Cardiolipin Metabolic Process Transcription Coregulator Activity Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Response To Thyroglobulin Triiodothyronine Glucose Import In Response To Insulin Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production TRAM-dependent Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Nuclear Envelope RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Aryl Hydrocarbon Receptor Binding Intracellular Receptor Signaling Pathway Nuclear Pore Nuclear Basket Nuclear Inclusion Body Kinase Activator Activity Nuclear Membrane Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process Cristae Formation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Locomotor Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Endosome To Plasma Membrane Protein Transport Vesicle Fusion To Plasma Membrane MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
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