CHGB and OGG1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		CHGB	OGG1
Name		chromogranin B	8-oxoguanine DNA glycosylase
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Matrix Nuclear Speck Protein-containing Complex
	Molecular Function	Hormone Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Catalytic Activity Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Lyase Activity Enzyme Binding Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Signal Transduction	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair Regulation Of DNA-templated Transcription DNA Damage Response Response To Oxidative Stress Response To Radiation Cellular Response To Reactive Oxygen Species Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Depurination Depyrimidination Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing
GWAS		Metabolite levels ( 23823483 ) Uterine fibroid number (single vs multiple) ( 30196971 )	No GWAS studies recorded
Interacting Genes		34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAFAZZIN TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	7 interacting genes: CHGB HUS1 NEDD4L PRKCA RAD1 RAD9A XRCC1
Entrez ID		1114	4968
HPRD ID		07512	03582
Ensembl ID		ENSG00000089199	ENSG00000114026
Uniprot IDs		P05060	A0A9L9PXU1 E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527
PDB IDs		Not available	1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13 7AYY 8VWT 8VWV 8VX4 8VX6 9EOZ
GO Terms Enriched among Interactors		Nucleotide Binding Cytoplasm Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Manganese Ion Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential GTP Binding Leukocyte Aggregation RAGE Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Manganese Ion Identical Protein Binding Regulation Of Developmental Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Golgi-associated Vesicle Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Catecholamine Stimulus Positive Regulation Of Proteolysis Response To Catecholamine Developmental Maturation ATP Binding Protein Tetramerization Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Membrane Organization Extracellular Exosome Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Defense Response Growth Cone Lamellipodium Regulation Of Growth Regulation Of Cell Projection Organization Regulation Of Cell Activation Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Amylin Binding	Checkpoint Clamp Complex Cellular Response To Ionizing Radiation Double-stranded DNA 3'-5' DNA Exonuclease Activity Meiotic Cell Cycle Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition DNA Metabolic Process DNA Damage Response Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Enzyme Binding Oxidized DNA Binding Regulation Of Cell Cycle Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Nucleoplasm Telomere Maintenance Meiotic DNA Integrity Checkpoint Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Protein ADP-ribosylation Telomere Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Meiotic Recombination Checkpoint Signaling ADP-D-ribose Modification-dependent Protein Binding Telomeric DNA-containing Double Minutes Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Sodium Ion Import Across Plasma Membrane Protein Kinase C Signaling ERCC4-ERCC1 Complex Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Regulation Of Base-excision Repair Positive Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stress Regulation Of Angiotensin-activated Signaling Pathway Sodium Ion Transport Regulation Of Cell Cycle Process