CHGB and RAC2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CHGB	RAC2
Gene Name		chromogranin B (secretogranin 1)	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Secretory Granule	Nuclear Envelope Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Extracellular Vesicular Exosome
	Molecular Function	Hormone Activity Protein Binding	GTPase Activity GTP Binding
	Biological Process		Actin Filament Organization Signal Transduction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Platelet Activation Bone Resorption Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Respiratory Burst Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration
Pathways			Signaling by GPCR Axon guidance Semaphorin interactions Signaling by Wnt beta-catenin independent WNT signaling Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation PCP/CE pathway Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			Graves' disease ( 23612905) Longevity ( 20834067)
Protein-Protein Interactions		31 interactors: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 MARK3 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SGK223 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	20 interactors: ACTB ADAM22 AFG3L2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		1114	5880
HPRD ID		07512	03628
Ensembl ID		ENSG00000089199	ENSG00000128340
Uniprot IDs		P05060	P15153
PDB IDs			1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Developmental Growth Cellular Metabolic Process Cellular Component Assembly Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Cell Differentiation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Synaptic Transmission Response To Metal Ion Response To Lipid Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cell Development Generation Of Neurons Response To Growth Factor Phosphate-containing Compound Metabolic Process Response To Organic Cyclic Compound Protein Homotetramerization Platelet Activation Positive Regulation Of Metabolic Process Response To Stress Metabolic Process Neurogenesis Response To Organic Substance Positive Regulation Of Lamellipodium Assembly Cellular Process Apoptotic Process Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Defense Response Hemostasis DNA-templated Transcription, Initiation Negative Regulation Of Developmental Growth Response To Wounding Long Term Synaptic Depression Programmed Cell Death Regulation Of Neurogenesis Nucleotide-excision Repair Positive Regulation Of Lamellipodium Organization Negative Regulation Of Growth Cell Death Death Cell Development Regulation Of Protein Import Into Nucleus, Translocation Developmental Process Regulation Of Cell Morphogenesis Response To Inorganic Substance	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Developmental Process Multicellular Organismal Development Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurogenesis Signal Transduction Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Response To External Stimulus Superoxide Metabolic Process Signaling Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Communication Anatomical Structure Development Response To Stimulus System Development Cell Differentiation Positive Regulation Of Metabolic Process Generation Of Neurons Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Regulation Of Cell Morphogenesis Innate Immune Response Midbrain Development SMAD Protein Complex Assembly Cellular Response To Stimulus Axonogenesis Defense Response Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Reactive Oxygen Species Metabolic Process Regulation Of Cell Adhesion Neuron Projection Morphogenesis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Defense Response To Virus By Virus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Localization Cell Development
Tagcloud ?		adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von	aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Difference) ?		adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von	aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Intersection) ?