CHGB and ACACA

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHGB	ACACA
Description		chromogranin B	acetyl-CoA carboxylase alpha
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule	Fibrillar Center Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton
	Molecular Function	Hormone Activity Protein Binding	Nucleotide Binding Catalytic Activity Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction	Tissue Homeostasis Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis
Drugs			Biotin
Diseases
GWAS		Metabolite levels ( 23823483) Uterine fibroid number (single vs multiple) ( 30196971)	Daytime nap ( 33568662) Ovarian cancer ( 23535730)
Interacting Genes		34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAFAZZIN TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1	15 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 NEIL3 PRKAA1 PRKAA2 PRKAB1 PRKAG1 TRIB1 TRIB2 TRIB3
Entrez ID		1114	31
HPRD ID		07512	01938
Ensembl ID		ENSG00000089199	ENSG00000278540
Uniprot IDs		P05060	Q13085 Q7Z5W8
PDB IDs			2YL2 3COJ 4ASI 6G2D 6G2H 6G2I 8XKZ 8XL0 8XL1 8XL2
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Cytoplasm Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Manganese Ion Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential GTP Binding Leukocyte Aggregation RAGE Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Manganese Ion Identical Protein Binding Regulation Of Developmental Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Golgi-associated Vesicle Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Catecholamine Stimulus Positive Regulation Of Proteolysis Response To Catecholamine Developmental Maturation ATP Binding Protein Tetramerization Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Membrane Organization Extracellular Exosome Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Defense Response Growth Cone Lamellipodium Regulation Of Growth Regulation Of Cell Projection Organization Regulation Of Cell Activation Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Amylin Binding	Nucleotide-activated Protein Kinase Complex Ubiquitin-protein Transferase Regulator Activity AMP-activated Protein Kinase Activity Fatty Acid Biosynthetic Process Mitogen-activated Protein Kinase Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Small Molecule Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Phosphorus Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Lipid Metabolic Process Carboxylic Acid Biosynthetic Process Protein Kinase CK2 Complex Protein Kinase Activity Protein Localization To Lipid Droplet Fatty Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Catabolic Process Protein Kinase Inhibitor Activity Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Tubulin Deacetylation CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Cellular Response To Glucose Starvation Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Tubulin Deacetylation Regulation Of Glycolytic Process Lipid Droplet Disassembly Regulation Of Proteolysis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Lipid Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MAP Kinase Activity Cellular Response To Stress Negative Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Phosphatidylethanolamine Biosynthetic Process Small Molecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Protein Deacetylation
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