TAFAZZIN and CCDC88C

Data Source: HiPPIP (Novel)

		TAFAZZIN	CCDC88C
Name		tafazzin, phospholipid-lysophospholipid transacylase	coiled-coil and HOOK domain protein 88C
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane	Extracellular Region Cytoplasm Centrosome Cell Junction Apical Junction Complex Anchoring Junction
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Transferase Activity Acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Frizzled Binding Protein Binding Microtubule Binding PDZ Domain Binding Identical Protein Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inner Mitochondrial Membrane Organization Cardiolipin Acyl-chain Remodeling Cristae Formation Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process	Microtubule Bundle Formation Cilium Movement Apical Constriction Negative Regulation Of Microtubule Depolymerization Signal Transduction Small GTPase-mediated Signal Transduction Wnt Signaling Pathway Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Protein Destabilization Non-canonical Wnt Signaling Pathway Cilium Organization Positive Regulation Of JNK Cascade Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Mucociliary Clearance Respiratory Basal Cell Differentiation
Pathways		Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL	Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Diseases		Dilated cardiomyopathy (DCM) Barth syndrome (BTHS) 3-Methylglutaconic aciduria (MGCA)	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 23535729 29059683 ) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226 ) Daytime sleep phenotypes ( 27126917 ) Proportion of activated microglia (inferior temporal cortex) ( 30679421 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Novel Interactors		7 novel interactors: CCDC88C OPN1LW RPL10 SLC6A8 SSR4 TRAK2 VBP1	2 novel interactors: TAFAZZIN TSC22D1
Interacting Genes		12 interacting genes: BTRC CFTR CHGB CSNK1E GSK3B LATS2 NHERF2 NONO RUNX1 USP14 USP26 YWHAE	9 interacting genes: APP DVL1 FBXO7 FZD6 FZD7 GNAI3 ITSN2 MAPK8 MPDZ
Entrez ID		6901	440193
HPRD ID		02316	19136
Ensembl ID		ENSG00000102125	ENSG00000015133
Uniprot IDs		A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A6XNE1 Q16635	B4DZB8 Q9P219
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Wnt Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Rhythmic Process Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Negative Regulation Of Protein Catabolic Process Deubiquitinase Activity Negative Regulation Of Protein Metabolic Process Hippo Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Rhythm Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Microtubule Anchoring At Centrosome Creatine:sodium Symporter Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Hippo Signaling Protein Modification Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Proteolysis Non-canonical Wnt Signaling Pathway Negative Regulation Of Metabolic Process	Frizzled Binding Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Catabolic Process Canonical Wnt Signaling Pathway Collateral Sprouting Wnt Receptor Activity Neuronal Dense Core Vesicle Protein Serine/threonine Kinase Binding Apicolateral Plasma Membrane Wnt-protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Macroautophagy Neuron Projection Organization Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Activation Modulation Of Excitatory Postsynaptic Potential Wnt Signaling Pathway JUN Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Neuron Projection Regulation Of Purine Nucleotide Metabolic Process G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization To Presynapse Positive Regulation Of Cardiolipin Metabolic Process Clathrin-dependent Synaptic Vesicle Endocytosis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import