TAL1 and ZHX1

Number of citations of the paper that reports this interaction (PubMedID 15383276)
0

Data Source:
HPRD (two hybrid)

		TAL1	ZHX1
Description		TAL bHLH transcription factor 1, erythroid differentiation factor	zinc fingers and homeoboxes 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Central Nervous System Neuron Differentiation Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein-containing Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Population Proliferation Erythrocyte Maturation Cell Fate Commitment Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Generation Of Neurons Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Chromatin Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		23 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1	54 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZBED1 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX
Entrez ID		6886	11244
HPRD ID		01753	10379
Ensembl ID		ENSG00000162367	ENSG00000165156
Uniprot IDs		P17542 Q16509	Q9UKY1
PDB IDs		2YPA 2YPB	2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process BHLH Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Chromatin Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Cell Population Proliferation Transcription Coactivator Binding Regulation Of Multicellular Organismal Process E-box Binding Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death Transcription Repressor Complex Eosinophil Fate Commitment Negative Regulation Of Programmed Cell Death Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity P53 Binding Cell Fate Commitment Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly RNA Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Response To Radiation Regulation Of Release Of Cytochrome C From Mitochondria RNA Binding Positive Regulation Of Metabolic Process Protein Tag Activity Cellular Response To Stress Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Apoptotic Signaling Pathway DNA Damage Response Regulation Of Mitochondrial Membrane Permeability RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Transferase Activity Protein Binding Regulation Of Cellular Response To Stress
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