TAL1 and NCAPG2

Number of citations of the paper that reports this interaction (PubMedID 14729962)
31

Data Source:
HPRD (two hybrid)

		TAL1	NCAPG2
Description		TAL bHLH transcription factor 1, erythroid differentiation factor	non-SMC condensin II complex subunit G2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex	Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Membrane Nuclear Speck Nuclear Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding	Protein Binding BHLH Transcription Factor Binding Histone H4K20me1 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Central Nervous System Neuron Differentiation Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein-containing Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Population Proliferation Erythrocyte Maturation Cell Fate Commitment Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Generation Of Neurons Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Chromatin Organization	Mitotic Sister Chromatid Segregation Inner Cell Mass Cell Proliferation Chromatin Organization Transcription By RNA Polymerase II Erythrocyte Differentiation Chromosome Condensation Cell Division Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	Condensation of Prophase Chromosomes
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Hearing loss in noise exposure ( 33242228) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Number of sexual partners ( 30643258) Plateletcrit ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Testicular germ cell tumor ( 28604732)
Interacting Genes		23 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1	4 interacting genes: CEBPA PLK1 TAL1 UBC
Entrez ID		6886	54892
HPRD ID		01753	10539
Ensembl ID		ENSG00000162367	ENSG00000146918
Uniprot IDs		P17542 Q16509	B3KRQ2 Q86XI2
PDB IDs		2YPA 2YPB
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process BHLH Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Chromatin Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Cell Population Proliferation Transcription Coactivator Binding Regulation Of Multicellular Organismal Process E-box Binding Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death Transcription Repressor Complex Eosinophil Fate Commitment Negative Regulation Of Programmed Cell Death Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity P53 Binding Cell Fate Commitment Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Granulocyte Differentiation Positive Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Maturation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Chromatin Response To Vitamin B2 White Fat Cell Proliferation Regulation Of Cell Cycle C/EBP Complex Cell Maturation Positive Regulation Of Proteasomal Protein Catabolic Process Myeloid Leukocyte Differentiation Regulation Of Cell Division Synaptonemal Complex Disassembly Golgi Inheritance Regulation Of Mast Cell Differentiation Hemangioblast Cell Differentiation Positive Regulation Of Chromatin Organization Basophil Differentiation Astrocyte Fate Commitment Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Regulation Of Chromosome Organization Myeloid Cell Differentiation Transcription Cis-regulatory Region Binding Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of DNA-templated Transcription Response To Phenylpropanoid Negative Regulation Of RNA Biosynthetic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Fat Cell Proliferation Metaphase/anaphase Transition Of Cell Cycle Glial Cell Fate Commitment Negative Regulation Of RNA Metabolic Process
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