TAL1 and SKP2

Number of citations of the paper that reports this interaction (PMID 17962192)
10

Data Source:
HPRD (in vivo)

		TAL1	SKP2
Gene Name		T-cell acute lymphocytic leukemia 1	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Transcription Factor Complex Lsd1/2 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Stem Cell Maintenance	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion
Pathways			APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1	54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		6886	6502
HPRD ID		01753	03256
Ensembl ID		ENSG00000162367	ENSG00000145604
Uniprot IDs		P17542	Q13309
PDB IDs		2YPA 2YPB	1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Embryo Development Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Blood Coagulation Hemostasis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromosome Organization Negative Regulation Of Binding Regulation Of Hormone Metabolic Process Regulation Of Erythrocyte Differentiation Regulation Of Body Fluid Levels Biosynthetic Process Wound Healing Hemopoiesis Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Histone Modification Immune System Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process
Tagcloud ?		activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line lymphoblastic model oncogene oncogenes originally postulates proposed restored subsequently suggests supporting suppressing transcriptional underwent	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Difference) ?		activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line lymphoblastic model oncogene oncogenes originally postulates proposed restored subsequently suggests supporting suppressing transcriptional underwent	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Intersection) ?