TAL1 and DRG1

Number of citations of the paper that reports this interaction (PubMedID 9824680)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TAL1	DRG1
Description		TAL bHLH transcription factor 1, erythroid differentiation factor	developmentally regulated GTP binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Hydrolase Activity Potassium Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Central Nervous System Neuron Differentiation Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein-containing Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Population Proliferation Erythrocyte Maturation Cell Fate Commitment Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Generation Of Neurons Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Chromatin Organization	Cytoplasmic Translation Positive Regulation Of Microtubule Polymerization Regulation Of Mitotic Spindle Assembly
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	Protein hydroxylation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Fish- and plant-related diet ( 32066663) Neutrophil count ( 27863252 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		23 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1	18 interacting genes: CAPNS1 CEBPA CFTR CLDN1 COIL LNX1 LYL1 MEOX2 PHC2 PTEN RWDD1 SKIL SRPK2 SSX2IP STK16 TAL1 UBE2I ZC3H15
Entrez ID		6886	4733
HPRD ID		01753	16034
Ensembl ID		ENSG00000162367	ENSG00000185721
Uniprot IDs		P17542 Q16509	Q9Y295
PDB IDs		2YPA 2YPB	2EKI
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process BHLH Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Chromatin Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Cell Population Proliferation Transcription Coactivator Binding Regulation Of Multicellular Organismal Process E-box Binding Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death Transcription Repressor Complex Eosinophil Fate Commitment Negative Regulation Of Programmed Cell Death Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity P53 Binding Cell Fate Commitment Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Developmental Maturation Response To Ketone Protein-containing Complex PDZ Domain Binding Definitive Hemopoiesis Lens Fiber Cell Differentiation Synapse Maturation Anatomical Structure Formation Involved In Morphogenesis PML Body Granulocyte Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of Cell Cycle Cell Maturation Enzyme Binding 14-3-3 Protein Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Synaptic Vesicle Clustering Hemangioblast Cell Differentiation SUMO Conjugating Enzyme Activity Xenobiotic Transport Across Blood-nerve Barrier Regulation Of Cell Population Proliferation Protein Domain Specific Binding Chromatin Binding Regulation Of RNA Metabolic Process Nucleus Regulation Of Cell Development Cellular Developmental Process Animal Organ Regeneration Response To Vitamin B2 Multicellular Organismal-level Homeostasis C/EBP Complex Identical Protein Binding Positive Regulation Of Anion Channel Activity Cell Junction Organization Negative Regulation Of Cell-substrate Adhesion Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Basophil Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Butyrate
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