TAL1 and HOXB9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TAL1	HOXB9
Description		TAL bHLH transcription factor 1, erythroid differentiation factor	homeobox B9
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Central Nervous System Neuron Differentiation Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein-containing Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Population Proliferation Erythrocyte Maturation Cell Fate Commitment Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Generation Of Neurons Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Chromatin Organization	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Mammary Gland Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cell Chemotaxis
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Celiac disease ( 24999842)
Interacting Genes		23 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1	66 interacting genes: BPIFA1 BTG1 BTG2 CALCOCO2 CARD10 CREBBP CYSRT1 EP300 EXOSC8 FAM168B FHL5 GOLGA2 GOLGA6L9 HOPX HOXA1 HSPB2 HSPB2-C11orf52 ING4 KAT2B KRT27 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP17-1 KRTAP19-5 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 LZTS2 MDFI MID2 MTUS2 MYBBP1A NBPF19 NOTCH2NLA OIP5 PCSK5 PFDN5 PHTF1 PLEKHG4 PNMA1 POLR1C RBPMS SAT1 SFMBT1 SIRT1 SPZ1 TAL1 TENM4 TET2 TNS2 TRIM27 TRIP6 ZNF408
Entrez ID		6886	3219
HPRD ID		01753	00852
Ensembl ID		ENSG00000162367	ENSG00000170689
Uniprot IDs		P17542 Q16509	B3KPJ1 P17482
PDB IDs		2YPA 2YPB
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process BHLH Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Chromatin Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Cell Population Proliferation Transcription Coactivator Binding Regulation Of Multicellular Organismal Process E-box Binding Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death Transcription Repressor Complex Eosinophil Fate Commitment Negative Regulation Of Programmed Cell Death Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity P53 Binding Cell Fate Commitment Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Intermediate Filament Keratin Filament N-terminal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Protein Acetylation Transcription Coactivator Activity Histone Acetyltransferase Complex Cytosol N-terminal Protein Amino Acid Acetylation Histone H3K27 Acetyltransferase Activity Regulation Of Cellular Response To Heat Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Diamine N-acetyltransferase Activity Acetyltransferase Activity Structural Constituent Of Skin Epidermis Identical Protein Binding Protein-lysine-acetyltransferase Activity Transcription Corepressor Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Histone Acetyltransferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Regulation Of Transcription By Glucose Protein Binding Internal Protein Amino Acid Acetylation Structural Molecule Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Epigenetic Regulation Of Gene Expression Chromatin Remodeling Pre-mRNA Intronic Binding Transcription Initiation-coupled Chromatin Remodeling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?