KLF5 and SET

Number of citations of the paper that reports this interaction (PMID 14612398)
30

Data Source:
HPRD (in vitro, in vivo)

		KLF5	SET
Gene Name		Kruppel-like factor 5 (intestinal)	SET nuclear proto-oncogene
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Metal Ion Binding	DNA Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Microvillus Assembly Regulation Of Microvillus Assembly Skeletal Muscle Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intestinal Epithelial Cell Development Cellular Response To Organic Cyclic Compound Cellular Response To Peptide	Mitotic Cell Cycle DNA Replication Nucleosome Assembly Nucleosome Disassembly Nucleocytoplasmic Transport Gene Expression Negative Regulation Of Histone Acetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity
Pathways		Transcriptional regulation of white adipocyte differentiation	Regulation of mRNA stability by proteins that bind AU-rich elements Mitotic Prophase Condensation of Prophase Chromosomes HuR stabilizes mRNA Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Pancreatic cancer ( 20101243)	Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		18 interactors: CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HDAC1 NFKB1 PRKCA PRKCD RARA SET SMURF2 TBP WWP1	51 interactors: ANP32A APEX1 APP CALM1 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 EP300 FAM111B FOS GZMA GZMK HDAC1 HIST1H2BA HIST1H3A HIST2H4A HIST3H3 HIST4H4 HMGB2 IRF1 JUNB KLF5 KMT2A MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PIK3CG PPP2CA PPP2R1B PRKAR1A PTMA RAC1 SDCBP SETBP1 SGOL1 TAF1A TERF1 TERF2 TERF2IP THAP7 TP53 TREX1 UCHL5
Entrez ID		688	6418
HPRD ID		04212	09023
Ensembl ID		ENSG00000102554	ENSG00000119335
Uniprot IDs		A2TJX0 Q13887 Q5T6X2	Q01105 Q5VXV3
PDB IDs		2EBT	2E50
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Nitrogen Compound Metabolic Process Viral Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process	Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Telomere Maintenance Developmental Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Cycle Process Cellular Metabolic Process DNA Replication-dependent Nucleosome Assembly Cell Cycle Transcription, DNA-templated Organelle Organization Regulation Of Gene Expression, Epigenetic Blood Coagulation Positive Regulation Of Protein Metabolic Process Chromatin Assembly RNA Biosynthetic Process Cellular Component Assembly Hemostasis Chromatin Organization Negative Regulation Of Cell Cycle Anatomical Structure Development Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Negative Regulation Of Gene Expression
Tagcloud ?		3t3 activities adipocyte adipocytes adipogenesis adipogenic ampk ap2 atorvastatin attractive cascades combination diseases ebpalpha elevated excessive exerts homeostasis l1 master metformin obesity ppargamma regulator regulators smad7 stat3 suppressed tgf	already assessing cognition cognitive cogs computation correlating costs cps deterioration easy estimate exam global inasmuch mds meaningful mental mini minimum msd quite residents scale scales simple slightly straightforward substantially utility
Tagcloud (Difference) ?		3t3 activities adipocyte adipocytes adipogenesis adipogenic ampk ap2 atorvastatin attractive cascades combination diseases ebpalpha elevated excessive exerts homeostasis l1 master metformin obesity ppargamma regulator regulators smad7 stat3 suppressed tgf	already assessing cognition cognitive cogs computation correlating costs cps deterioration easy estimate exam global inasmuch mds meaningful mental mini minimum msd quite residents scale scales simple slightly straightforward substantially utility
Tagcloud (Intersection) ?