KLF5 and ATXN3L

Number of citations of the paper that reports this interaction (PubMedID 26079537)
26

Data Source:
BioGRID (enzymatic study)

		KLF5	ATXN3L
Description		KLF transcription factor 5	ataxin 3 like
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding MRF Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration Positive Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of ERAD Pathway
Pathways		Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis	Josephin domain DUBs
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Aspartate aminotransferase levels ( 33547301) Asthma ( 34103634) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 31959993) Keratoconus ( 33649486) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 20101243 29422604 26098869 25086665) Prostate cancer ( 26443449 31562322) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)	Bipolar disorder ( 31043756)
Interacting Genes		26 interacting genes: ANP32B ATXN3L CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NEDD4 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I	8 interacting genes: KLF5 PJA1 RFFL TRIM54 TRIM55 TRIM63 UBC USP28
Entrez ID		688	92552
HPRD ID		04212	19697
Ensembl ID		ENSG00000102554	ENSG00000123594
Uniprot IDs		Q13887 Q5T6X2	B4DYC7 Q9H3M9
PDB IDs		2EBT	3O65
Enriched GO Terms of Interacting Partners?		Nucleoplasm Transcription By RNA Polymerase II Enzyme Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cellular Response To UV DNA Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coregulator Binding Protein-containing Complex Response To Lipid Positive Regulation Of Protein Localization Cellular Response To Light Stimulus Transcription Coactivator Binding	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Zinc Ion Binding Positive Regulation Of Transcription By Transcription Factor Localization Protein Metabolic Process Microtubule Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein K48-linked Ubiquitination Satellite Cell Activation Involved In Skeletal Muscle Regeneration Metal Ion Binding Z Disc Myotube Differentiation Involved In Skeletal Muscle Regeneration MRF Binding Skeletal Muscle Atrophy Microvillus Assembly Skeletal Muscle Satellite Cell Activation Innate Immune Response Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Diapedesis Skeletal Muscle Adaptation Striated Muscle Atrophy
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