KLF5

Name	KLF transcription factor 5
Structure
Interactors	26 interactors: ANP32B ATXN3L CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NEDD4 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding MRF Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration Positive Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin
Pathways	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis
GWAS	Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657 ) Aspartate aminotransferase levels ( 33547301 ) Asthma ( 34103634 ) Blood urea nitrogen levels ( 31152163 ) Breast cancer ( 27117709 ) Breast cancer (estrogen-receptor negative) ( 27117709 29058716 ) Breast Cancer in BRCA1 mutation carriers ( 29058716 ) Chronotype ( 30696823 ) Colorectal cancer ( 30529582 ) Colorectal cancer or advanced adenoma ( 30510241 ) Creatine kinase levels ( 29403010 ) Endometrial cancer ( 27008869 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Glaucoma (primary open-angle) ( 33627673 ) Intraocular pressure ( 29785010 31959993 ) Keratoconus ( 33649486 ) Lymphocyte percentage of white cells ( 32888494 ) Mitochondrial heteroplasmy measurement ( 33731350 ) Monocyte count ( 32888494 ) Neutrophil count ( 32888494 ) Pancreatic cancer ( 20101243 29422604 26098869 25086665 ) Prostate cancer ( 26443449 31562322 ) Systolic blood pressure ( 30224653 ) Type 2 diabetes ( 25760438 )
Entrez ID	688
HPRD ID	04212
Ensembl ID	ENSG00000102554
Uniprot IDs	Q13887 Q5T6X2
PDB IDs	2EBT
GO Terms Enriched among Interactors ?	Nucleoplasm Transcription By RNA Polymerase II Enzyme Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cellular Response To UV DNA Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coregulator Binding Protein-containing Complex Response To Lipid Positive Regulation Of Protein Localization Cellular Response To Light Stimulus Transcription Coactivator Binding