TAC1 and BAG6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		TAC1	BAG6
Gene Name		tachykinin, precursor 1	BCL2-associated athanogene 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle BAT3 Complex
	Molecular Function	Protein Binding Substance P Receptor Binding	Protein Binding Hsp70 Protein Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding Ribosome Binding Proteasome Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Corticosterone Secretion	Kidney Development Immune System Process Ubiquitin-dependent Protein Catabolic Process Transport Synaptonemal Complex Assembly Spermatogenesis Brain Development Embryo Development Chromatin Modification Internal Peptidyl-lysine Acetylation Cell Differentiation Lung Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Protein Stabilization Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Adverse response to radiation therapy ( 23719583) Response to platinum-based agents ( 22020760)	Schizophrenia ( 23894747)
Protein-Protein Interactions		12 interactors: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TAC4 TACR1 TACR2 TACR3 TFF2 XRCC6	102 interactors: ACVR1B AMFR ANXA7 ARPC3 ATN1 ATXN2 B2M C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CHN2 CLU CSNK2B CSTF2 CTCFL CTSB CTSE CTSL CXCL8 DNAJB11 DPT EDN1 EFEMP1 EFEMP2 EP300 FAM173A FAM46A FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GSK3B HSPA13 HSPA8 ICK IGF2 IGFBP5 IKBKAP IMMT IQCG KLHL12 LBP LPPR3 MAPK6 MAVS MEST MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 POLR2J PPAP2C PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TDGF1 TFCP2 TK1 TOMM20 TP63 TTR UBL4A UBL7 UBQLN4 VAMP2 XRN1 ZFYVE9
Entrez ID		6863	7917
HPRD ID		08876	00808
Ensembl ID		ENSG00000006128	ENSG00000204463
Uniprot IDs		P20366 Q9Y494	P46379
PDB IDs		2B19 2KS9 2KSA 2KSB	1WX9 4DWF 4EEW
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Regulation Of Smooth Muscle Contraction Operant Conditioning Regulation Of Saliva Secretion Hyperosmotic Salinity Response Neuropeptide Signaling Pathway Blood Circulation Positive Regulation Of Digestive System Process Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Hyperosmotic Response Regulation Of Blood Pressure Regulation Of Vascular Permeability Response To Salt Stress Positive Regulation Of Blood Pressure Response To Morphine Regulation Of Secretion Response To Electrical Stimulus Excretion Smooth Muscle Contraction Positive Regulation Of Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Acute Inflammatory Response Response To Osmotic Stress Response To Ammonium Ion Positive Regulation Of Synaptic Transmission Cellular Hyperosmotic Salinity Response Smooth Muscle Contraction Involved In Micturition Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Response To Abiotic Stimulus Digestion Response To Estradiol G-protein Coupled Receptor Signaling Pathway Regulation Of Acetylcholine Secretion, Neurotransmission Calcium-independent Cell-matrix Adhesion Learning Positive Regulation Of Synaptic Transmission, Cholinergic Response To Alkaloid Synaptic Transmission Prolactin Secretion Cellular Response To X-ray Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Gonadotropin Secretion Micturition Response To Ozone	Response To Organic Substance Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Immune System Process Regulation Of Protein Phosphorylation Cellular Response To Stimulus Defense Response Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response Regulation Of Cell Cycle Response To External Stimulus Signal Transduction Developmental Process Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cell Development System Development Regulation Of Phosphorylation Regulation Of Signal Transduction Response To Hormone Immune System Process Response To Lipid Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Protein Metabolic Process Regulation Of Cellular Process Cellular Process Regulation Of Catalytic Activity Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Regulation Of Cell Motility Apoptotic Signaling Pathway Multicellular Organismal Development Positive Regulation Of Signal Transduction
Tagcloud ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd	biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides sgta solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Difference) ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd	biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides sgta solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Intersection) ?