TAC1 and TACR1

Number of citations of the paper that reports this interaction (PMID 12548712)
9

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		TAC1	TACR1
Gene Name		tachykinin, precursor 1	tachykinin receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Cell Body
	Molecular Function	Protein Binding Substance P Receptor Binding	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Corticosterone Secretion	Aggressive Behavior Acute Inflammatory Response Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Long-term Memory Associative Learning Response To Heat Detection Of Abiotic Stimulus Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Positive Regulation Of Renal Sodium Excretion Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Morphine Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Saliva Secretion Positive Regulation Of Hormone Secretion Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Positive Regulation Of Uterine Smooth Muscle Contraction
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Aprepitant Ketamine Vapreotide
Diseases
GWAS		Adverse response to radiation therapy ( 23719583) Response to platinum-based agents ( 22020760)	Brain connectivity ( 23471985)
Protein-Protein Interactions		12 interactors: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TAC4 TACR1 TACR2 TACR3 TFF2 XRCC6	5 interactors: GPRASP1 GRK5 TAC1 TAC3 TAC4
Entrez ID		6863	6869
HPRD ID		08876	01208
Ensembl ID		ENSG00000006128	ENSG00000115353
Uniprot IDs		P20366 Q9Y494	P25103
PDB IDs		2B19 2KS9 2KSA 2KSB	2KS9 2KSA 2KSB
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Regulation Of Smooth Muscle Contraction Operant Conditioning Regulation Of Saliva Secretion Hyperosmotic Salinity Response Neuropeptide Signaling Pathway Blood Circulation Positive Regulation Of Digestive System Process Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Hyperosmotic Response Regulation Of Blood Pressure Regulation Of Vascular Permeability Response To Salt Stress Positive Regulation Of Blood Pressure Response To Morphine Regulation Of Secretion Response To Electrical Stimulus Excretion Smooth Muscle Contraction Positive Regulation Of Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Acute Inflammatory Response Response To Osmotic Stress Response To Ammonium Ion Positive Regulation Of Synaptic Transmission Cellular Hyperosmotic Salinity Response Smooth Muscle Contraction Involved In Micturition Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Response To Abiotic Stimulus Digestion Response To Estradiol G-protein Coupled Receptor Signaling Pathway Regulation Of Acetylcholine Secretion, Neurotransmission Calcium-independent Cell-matrix Adhesion Learning Positive Regulation Of Synaptic Transmission, Cholinergic Response To Alkaloid Synaptic Transmission Prolactin Secretion Cellular Response To X-ray Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Gonadotropin Secretion Micturition Response To Ozone	Tachykinin Receptor Signaling Pathway Positive Regulation Of Saliva Secretion Regulation Of Saliva Secretion Positive Regulation Of Digestive System Process G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Positive Regulation Of Corticosterone Secretion Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Corticosterone Secretion Regulation Of Synaptic Transmission, Cholinergic Cell Surface Receptor Signaling Pathway Blood Circulation Positive Regulation Of Secretion Positive Regulation Of Action Potential Negative Regulation Of Heart Rate Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Synaptic Transmission, GABAergic Insemination Receptor Catabolic Process Regulation Of Renal Sodium Excretion Copulation Negative Regulation Of Heart Contraction Regulation Of Excretion Positive Regulation Of Acute Inflammatory Response Endosome To Lysosome Transport Regulation Of Secretion Regulation Of Synaptic Transmission, GABAergic Response To Pain Response To Morphine Positive Regulation Of Transport Positive Regulation Of Stress Fiber Assembly Lysosomal Transport Long-term Memory Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Mating Positive Regulation Of Lipid Transport Signaling Regulation Of Stress Fiber Assembly Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Termination Of Signal Transduction Regulation Of Acute Inflammatory Response Regulation Of Heart Rate
Tagcloud ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd
Tagcloud (Difference) ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd
Tagcloud (Intersection) ?