TAC1 and TACR1

Number of citations of the paper that reports this interaction (PubMedID 12548712)
44

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		TAC1	TACR1
Description		tachykinin precursor 1	tachykinin receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Neuronal Cell Body Synapse Neuronal Dense Core Vesicle	Plasma Membrane Cell Surface Membrane Dendrite Sperm Flagellum Cell Body Postsynaptic Membrane Sperm Head Cell Periphery Sperm Midpiece
	Molecular Function	Protein Binding Substance P Receptor Binding Neuromedin K Receptor Binding Substance K Receptor Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Response To Yeast Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Innate Immune Response Positive Regulation Of Action Potential Positive Regulation Of Ossification Response To Pain Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Stress Fiber Assembly Regulation Of Sensory Perception Of Pain Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Sensory Perception Of Pain Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion	Aggressive Behavior Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Learning Or Memory Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Hormone Secretion Response To Pain Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events	Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS		Adventurousness ( 30643258) Adverse response to radiation therapy ( 23719583) Blood protein levels ( 30072576) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Regular attendance at a religious group ( 29970889) Response to platinum-based agents ( 22020760) Squamous cell lung carcinoma ( 28604730)	Bipolar disorder x sex interaction ( 34099189) Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6	7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147
Entrez ID		6863	6869
HPRD ID		08876	01208
Ensembl ID		ENSG00000006128	ENSG00000115353
Uniprot IDs		P20366 Q9Y494	P25103
PDB IDs		2B19 2KS9 2KSA 2KSB 4HOM 7P00 7P02 7RMG 7RMH 7VDM 7XWO 8JBH 8U26	2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP 7P00 7P02 7RMG 7RMH 7RMI 8U26
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Sperm Head Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Membrane Cyclin Binding Regulation Of Reproductive Process Response To Electrical Stimulus Peptide Hormone Processing Regulation Of Hormone Levels Signaling Receptor Ligand Precursor Processing Regulation Of Cell Motility Regulation Of Vascular Permeability Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Regulation Of Biological Quality Smooth Muscle Contraction Regulation Of Microtubule-based Process Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Maturation Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Angiotensin-mediated Drinking Behavior Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Regulation Of Multicellular Organismal Process	Tachykinin Receptor Signaling Pathway Substance K Receptor Binding Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Positive Regulation Of Sensory Perception Of Pain Regulation Of Microtubule-based Movement Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Reproductive Process Regulation Of Microtubule-based Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway G Protein-coupled Receptor Catabolic Process Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Motility Positive Regulation Of Corticosterone Secretion Protein Localization To Nuclear Inner Membrane Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Locomotion Detection Of Stimulus Involved In Sensory Perception Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Insemination Response To Temperature Stimulus Regulation Of Corticosterone Secretion G Protein-coupled Receptor Kinase Activity Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Action Potential Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Detection Of Stimulus Antifungal Humoral Response Nuclear Membrane Negative Regulation Of Heart Rate Protein Localization To Nuclear Envelope Response To Yeast Regulation Of Cell Motility
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