TAC1 and ARHGEF40

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TAC1	ARHGEF40
Gene Name		tachykinin, precursor 1	Rho guanine nucleotide exchange factor (GEF) 40
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body	Cytoplasm
	Molecular Function	Protein Binding Substance P Receptor Binding	Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Corticosterone Secretion	Positive Regulation Of Rho GTPase Activity
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Adverse response to radiation therapy ( 23719583) Response to platinum-based agents ( 22020760)
Protein-Protein Interactions		12 interactors: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TAC4 TACR1 TACR2 TACR3 TFF2 XRCC6	6 interactors: APP MAPT MYCBP SPERT STC2 TAC1
Entrez ID		6863	55701
HPRD ID		08876	13335
Ensembl ID		ENSG00000006128	ENSG00000165801
Uniprot IDs		P20366 Q9Y494	Q8TER5
PDB IDs		2B19 2KS9 2KSA 2KSB
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Regulation Of Smooth Muscle Contraction Operant Conditioning Regulation Of Saliva Secretion Hyperosmotic Salinity Response Neuropeptide Signaling Pathway Blood Circulation Positive Regulation Of Digestive System Process Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Hyperosmotic Response Regulation Of Blood Pressure Regulation Of Vascular Permeability Response To Salt Stress Positive Regulation Of Blood Pressure Response To Morphine Regulation Of Secretion Response To Electrical Stimulus Excretion Smooth Muscle Contraction Positive Regulation Of Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Acute Inflammatory Response Response To Osmotic Stress Response To Ammonium Ion Positive Regulation Of Synaptic Transmission Cellular Hyperosmotic Salinity Response Smooth Muscle Contraction Involved In Micturition Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Response To Abiotic Stimulus Digestion Response To Estradiol G-protein Coupled Receptor Signaling Pathway Regulation Of Acetylcholine Secretion, Neurotransmission Calcium-independent Cell-matrix Adhesion Learning Positive Regulation Of Synaptic Transmission, Cholinergic Response To Alkaloid Synaptic Transmission Prolactin Secretion Cellular Response To X-ray Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Gonadotropin Secretion Micturition Response To Ozone	Regulation Of Developmental Growth Reproduction Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Axon Cargo Transport Reproductive Process Mating Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Single-organism Behavior Metal Ion Homeostasis Cellular Chemical Homeostasis Associative Learning Developmental Cell Growth Ion Homeostasis Behavior Regulation Of Growth Regulation Of Multicellular Organism Growth Adult Locomotory Behavior Cellular Homeostasis Microtubule-based Transport Learning Cytoskeleton-dependent Intracellular Transport Sexual Reproduction Developmental Growth Involved In Morphogenesis Multicellular Organismal Reproductive Process Cell Growth Synaptic Growth At Neuromuscular Junction Positive Regulation Of Corticosterone Secretion Multicellular Organism Reproduction Chemical Homeostasis Adult Behavior Collateral Sprouting In Absence Of Injury Positive Regulation Of Cytoskeleton Organization Response To Abiotic Stimulus Locomotory Behavior Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Saliva Secretion Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Corticosterone Secretion Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Regulation Of Saliva Secretion Regulation Of Synaptic Transmission, Cholinergic Developmental Growth Cognition Positive Regulation Of Cellular Component Biogenesis
Tagcloud ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd
Tagcloud (Difference) ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd
Tagcloud (Intersection) ?