TAC1 and TACR2

Number of citations: 32 (PubMedID 11786503)
Data Source: BioGRID (pull down, pull down), HPRD (in vivo)

		TAC1	TACR2
Name		tachykinin precursor 1	tachykinin receptor 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Neuronal Cell Body Synapse Neuronal Dense Core Vesicle	Plasma Membrane Membrane Sperm Flagellum Sperm Head Sperm Midpiece
	Molecular Function	Protein Binding Substance P Receptor Binding Neuromedin K Receptor Binding Substance K Receptor Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance K Receptor Activity
	Biological Process	Response To Yeast Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Innate Immune Response Positive Regulation Of Action Potential Positive Regulation Of Ossification Response To Pain Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Stress Fiber Assembly Regulation Of Sensory Perception Of Pain Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Sensory Perception Of Pain Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion	Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Acetylcholine Secretion, Neurotransmission Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Operant Conditioning Positive Regulation Of Vascular Permeability Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Smooth Muscle Contraction Response To Electrical Stimulus Prolactin Secretion Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs		None	Saredutant
GWAS		Adventurousness ( 30643258 ) Adverse response to radiation therapy ( 23719583 ) Blood protein levels ( 30072576 ) Feeling nervous ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Regular attendance at a religious group ( 29970889 ) Response to platinum-based agents ( 22020760 ) Squamous cell lung carcinoma ( 28604730 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: CDK6 SGCE	1 novel interactors: ANK3
Interacting Genes		10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6	5 interacting genes: GPRASP1 MTDH TAC1 TAC3 TAC4
Entrez ID		6863	6865
HPRD ID		08876	01207
Ensembl ID		ENSG00000006128	ENSG00000075073
Uniprot IDs		P20366 Q9Y494	P21452
PDB IDs		2B19 2KS9 2KSA 2KSB 4HOM 7P00 7P02 7RMG 7RMH 7VDM 7XWO 8JBH 8U26	7XWO
GO Terms Enriched among Interactors		Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Sperm Head Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Membrane Cyclin Binding Regulation Of Reproductive Process Response To Electrical Stimulus Peptide Hormone Processing Regulation Of Hormone Levels Signaling Receptor Ligand Precursor Processing Regulation Of Cell Motility Regulation Of Vascular Permeability Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Regulation Of Biological Quality Smooth Muscle Contraction Regulation Of Microtubule-based Process Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Maturation Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Angiotensin-mediated Drinking Behavior Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Regulation Of Multicellular Organismal Process	Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Regulation Of Blood Pressure Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Reproductive Process Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Regulation Of Nervous System Process Positive Regulation Of Cell Motility G Protein-coupled Receptor Catabolic Process Bicellular Tight Junction Positive Regulation Of Locomotion Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Corticosterone Secretion Detection Of Stimulus Involved In Sensory Perception Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Insemination Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential G Protein-coupled Receptor Signaling Pathway Cellular Response To Magnesium Ion Regulation Of Corticosterone Secretion Intercellular Canaliculus Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Voltage-gated Potassium Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity