STX2 and SYT1

Number of citations of the paper that reports this interaction (PMID 10397765)
9

Data Source:
BioGRID (pull down)

		STX2	SYT1
Gene Name		syntaxin 2	synaptotagmin I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell-cell Junction Synaptic Vesicle Cell Surface Endomembrane System Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule SNARE Complex Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Protein Dimerization Activity Calcium-dependent Protein Binding	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Clathrin Binding Identical Protein Binding Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Intracellular Protein Transport Signal Transduction Acrosome Reaction Ectoderm Development Organ Morphogenesis Cell Differentiation Regulation Of Blood Coagulation Synaptic Vesicle Fusion To Presynaptic Membrane Response To Hydroperoxide Vesicle Docking Protein Oligomerization Regulation Of Cytoskeleton Organization	Detection Of Calcium Ion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Positive Regulation Of Synaptic Transmission Protein Homooligomerization Regulation Of Synaptic Transmission, Glutamatergic Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway
Pathways			Dopamine Neurotransmitter Release Cycle Toxicity of botulinum toxin type G (BoNT/G) Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: CPLX2 SNAP23 SNAP25 STXBP1 STXBP2 SYT1 SYT4 SYT7 UNC13B VAMP2 VAMP3 VAPB	30 interactors: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GNB2L1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17
Entrez ID		2054	6857
HPRD ID		11816	01710
Ensembl ID		ENSG00000111450	ENSG00000067715
Uniprot IDs		P32856	J3KQA0 P21579
PDB IDs			2K45 2K4A 2K8M 2KI6 2LHA 2R83 3F00 3F01 3F04 3F05 4ISQ
Enriched GO Terms of Interacting Partners?		Exocytosis Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Vesicle Docking Vesicle-mediated Transport Membrane Docking Regulation Of Secretion Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Vesicle Docking Involved In Exocytosis Establishment Of Localization In Cell Glutamate Secretion Cellular Localization Regulation Of Cellular Localization Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Establishment Of Organelle Localization Acid Secretion Organelle Localization Dicarboxylic Acid Transport Vesicle Organization Regulation Of Synaptic Transmission Synaptic Transmission Leukocyte Degranulation Transport Synaptic Vesicle Priming Vesicle Fusion Amino Acid Transport Regulation Of Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Organelle Fusion Membrane Organization Positive Regulation Of Synaptic Transmission Carboxylic Acid Transport Organic Acid Transport Anion Transport Membrane Fusion Regulation Of Vesicle Fusion Leukocyte Activation Involved In Immune Response Endomembrane System Organization Organic Anion Transport	Cell-cell Signaling Neurotransmitter Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Vesicle Localization Regulation Of Cellular Localization Exocytosis Regulation Of Signaling Organelle Localization Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Signaling Establishment Of Vesicle Localization Regulation Of Cellular Component Organization Cell Communication Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Cellular Localization Establishment Of Organelle Localization Vesicle Fusion Vesicle-mediated Transport Membrane Depolarization Membrane Fusion Acid Secretion Regulation Of Vesicle-mediated Transport Protein Localization Regulation Of Protein Localization Regulation Of Membrane Potential Organelle Fusion Regulation Of Secretion Glucocorticoid Receptor Signaling Pathway Regulation Of Immune Response Vesicle Docking Transport Regulation Of Synaptic Transmission Establishment Of Protein Localization Membrane Docking Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Calcium Ion-dependent Exocytosis Regulation Of Protein Secretion Regulation Of Cellular Process Cell Differentiation Protein Transport Regulation Of Protein Localization To Plasma Membrane Membrane Organization
Tagcloud ?		alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced toxigenic toxins transcripts untreated uremic xbp1	carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Difference) ?		alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced toxigenic toxins transcripts untreated uremic xbp1	carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Intersection) ?